Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F16%3A33161127" target="_blank" >RIV/61989592:15310/16:33161127 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1080/00958972.2016.1199862" target="_blank" >http://dx.doi.org/10.1080/00958972.2016.1199862</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00958972.2016.1199862" target="_blank" >10.1080/00958972.2016.1199862</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands

Popis výsledku v původním jazyce

Platinum(II) complexes, [Pt(L-x)X-2] (1-6), where X=Br or I and L-x=2,2-bipyridine or 1,10-phenanthroline derivatives (5,5-dimethyl-2,2-bipyridine (5-Mebpy), 4,4-dimethyl-2,2-bipyridine (4-Mebpy), and 5-amino-1,10-phenanthroline (5-NH(2)phen)) were prepared. The complexes were characterized by the elemental analysis, mass spectrometry, infrared, and multinuclear (H-1, C-13 and Pt-195) 1-D and 2-D NMR spectroscopies, and by single-crystal X-ray analysis of [Pt(4-Mebpy)I-2] (4). All the platinum(II) complexes (1-6) were evaluated for in vitro cytotoxicity against human cancer cell lines A2780 and A2780R, and against non-malignant MRC5 cell line. All the complexes were nontoxic up to the 50M concentration, although they were found to readily bind to calf-thymus DNA (CT-DNA), as determined by spectrophotometric titration (K-b approximate to 10(7)M(-1)) and ethidium bromide displacement assay.

Název v anglickém jazyce

Synthesis, characterization, DNA binding studies and in vitro cytotoxicity of platinum(II)-dihalogenido complexes containing bidentate chelating N-donor ligands

Popis výsledku anglicky

Platinum(II) complexes, [Pt(L-x)X-2] (1-6), where X=Br or I and L-x=2,2-bipyridine or 1,10-phenanthroline derivatives (5,5-dimethyl-2,2-bipyridine (5-Mebpy), 4,4-dimethyl-2,2-bipyridine (4-Mebpy), and 5-amino-1,10-phenanthroline (5-NH(2)phen)) were prepared. The complexes were characterized by the elemental analysis, mass spectrometry, infrared, and multinuclear (H-1, C-13 and Pt-195) 1-D and 2-D NMR spectroscopies, and by single-crystal X-ray analysis of [Pt(4-Mebpy)I-2] (4). All the platinum(II) complexes (1-6) were evaluated for in vitro cytotoxicity against human cancer cell lines A2780 and A2780R, and against non-malignant MRC5 cell line. All the complexes were nontoxic up to the 50M concentration, although they were found to readily bind to calf-thymus DNA (CT-DNA), as determined by spectrophotometric titration (K-b approximate to 10(7)M(-1)) and ethidium bromide displacement assay.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Coordination Chemistry

ISSN

0095-8972

e-ISSN

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Svazek periodika

69

Číslo periodika v rámci svazku

16

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

2422-2436

Kód UT WoS článku

000381359200004

EID výsledku v databázi Scopus

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