Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73584111" target="_blank" >RIV/61989592:15310/17:73584111 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0020169316306247" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0020169316306247</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2016.11.017" target="_blank" >10.1016/j.ica.2016.11.017</a>

Jazyk výsledku
angličtina
Název v původním jazyce
Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity
Popis výsledku v původním jazyce
Eight analogues of transplatin bearing 5-phenyltetrazolato and 5-(phenol)tetrazolato ligands were prepared and characterized. It was shown that due to the strong binding ability of the 5R-tetrazole to Pt, this ligand does not simply act as a bioisostere of a carboxylic acid but still imparts interesting biological activity to Pt(IV) complexes.
Název v anglickém jazyce
Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity
Popis výsledku anglicky
Eight analogues of transplatin bearing 5-phenyltetrazolato and 5-(phenol)tetrazolato ligands were prepared and characterized. It was shown that due to the strong binding ability of the 5R-tetrazole to Pt, this ligand does not simply act as a bioisostere of a carboxylic acid but still imparts interesting biological activity to Pt(IV) complexes.

Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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