Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F17%3A73584929" target="_blank" >RIV/61989592:15310/17:73584929 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-319-63001-4_14" target="_blank" >http://dx.doi.org/10.1007/978-3-319-63001-4_14</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-63001-4_14" target="_blank" >10.1007/978-3-319-63001-4_14</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Popis výsledku v původním jazyce

Cytokinins are phytohormones that regulate plant growth, development and senescence. Experiments both in vitro and in vivo demonstrate that they can also have diverse effects on animal cells and tissues. Particularly interesting is their ability to protect cells against various forms of stress and prevent some detrimental effects of cell aging. For example, human skin fibroblasts cultured in the presence of kinetin or trans-zeatin retain some characteristics of cells of lower passage. Kinetin is even able to increase the lifespan of invertebrates. In this chapter, we review protective effects of cytokinins in animals at molecular, cellular, tissue and organismal levels. We also discuss potential application of cytokinins for the treatment of age-related diseases, including neurodegenerations, inflammatory diseases and disorders caused by aberrant cell proliferation.

Název v anglickém jazyce

Plant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases

Popis výsledku anglicky

Cytokinins are phytohormones that regulate plant growth, development and senescence. Experiments both in vitro and in vivo demonstrate that they can also have diverse effects on animal cells and tissues. Particularly interesting is their ability to protect cells against various forms of stress and prevent some detrimental effects of cell aging. For example, human skin fibroblasts cultured in the presence of kinetin or trans-zeatin retain some characteristics of cells of lower passage. Kinetin is even able to increase the lifespan of invertebrates. In this chapter, we review protective effects of cytokinins in animals at molecular, cellular, tissue and organismal levels. We also discuss potential application of cytokinins for the treatment of age-related diseases, including neurodegenerations, inflammatory diseases and disorders caused by aberrant cell proliferation.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/LO1204" target="_blank" >LO1204: Udržitelný rozvoj výzkumu v Centru regionu Haná</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Hormones in Ageing and Longevity

ISBN

978-3-319-63000-7

Počet stran výsledku

25

Strana od-do

311-335

Počet stran knihy

335

Název nakladatele

Springer

Místo vydání

Heidelberg

Kód UT WoS kapitoly

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