A half-sandwich Ta-V dichlorido complex containing an O,N,O '-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73596422" target="_blank" >RIV/61989592:15310/19:73596422 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1107/S2053229619001323" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1107/S2053229619001323</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S2053229619001323" target="_blank" >10.1107/S2053229619001323</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A half-sandwich Ta-V dichlorido complex containing an O,N,O '-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity

Popis výsledku v původním jazyce

A new electroneutral half-sandwich tantalum(V) dichlorido complex containing pentamethylcyclopentadienyl (Cp*) and the double-deprotonated version of the Schiff base 2-ethoxy-6-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H2L) as ligands, namely cis-dichlorido(2-ethoxy-6-{(E)-[(2-oxidophenyl)imino]methyl}phenolato- kappa O-3,N,O&apos;)(eta(5)-pentamethylcyclopentadienyl)tantalum(V), [Ta(C10H15)(C15H13NO3)Cl-2] or [Ta(eta(5)-Cp*)(L)Cl-2], has been prepared and thoroughly characterized by elemental analysis, IR and NMR spectroscopy, mass spectrometry, density functional theory (DFT) calculations and single-crystal X-ray diffraction. The molecular structure revealed that the Ta-V centre is coordinated by a eta(5)-Cp* ligand, two monodentate chlorido ligands and one O,N,O&apos;-tridentate L2- ligand. The crystal structure is stabilized by C-H center dot center dot center dot C, C-H center dot center dot center dot Cl and C center dot center dot center dot C intermolecular interactions. Moreover, the complex shows notable in vitro cytotoxicity against the A2780 human ovarian carcinoma cell line, with IC50 = 14.4 mu M, which is higher than that of the conventional platinum-based anticancer drug cisplatin (IC50 = 20.1 mu M).

Název v anglickém jazyce

A half-sandwich Ta-V dichlorido complex containing an O,N,O '-tridentate Schiff base ligand: synthesis, crystal structure and in vitro cytotoxicity

Popis výsledku anglicky

A new electroneutral half-sandwich tantalum(V) dichlorido complex containing pentamethylcyclopentadienyl (Cp*) and the double-deprotonated version of the Schiff base 2-ethoxy-6-{(E)-[(2-hydroxyphenyl)imino]methyl}phenol (H2L) as ligands, namely cis-dichlorido(2-ethoxy-6-{(E)-[(2-oxidophenyl)imino]methyl}phenolato- kappa O-3,N,O&apos;)(eta(5)-pentamethylcyclopentadienyl)tantalum(V), [Ta(C10H15)(C15H13NO3)Cl-2] or [Ta(eta(5)-Cp*)(L)Cl-2], has been prepared and thoroughly characterized by elemental analysis, IR and NMR spectroscopy, mass spectrometry, density functional theory (DFT) calculations and single-crystal X-ray diffraction. The molecular structure revealed that the Ta-V centre is coordinated by a eta(5)-Cp* ligand, two monodentate chlorido ligands and one O,N,O&apos;-tridentate L2- ligand. The crystal structure is stabilized by C-H center dot center dot center dot C, C-H center dot center dot center dot Cl and C center dot center dot center dot C intermolecular interactions. Moreover, the complex shows notable in vitro cytotoxicity against the A2780 human ovarian carcinoma cell line, with IC50 = 14.4 mu M, which is higher than that of the conventional platinum-based anticancer drug cisplatin (IC50 = 20.1 mu M).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Crystallographica Section C-Structural Chemistry

ISSN

2053-2296

e-ISSN

—

Svazek periodika

75

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

248-254

Kód UT WoS článku

000460297900002

EID výsledku v databázi Scopus

2-s2.0-85061491119