Non-platinum complexes containing releasable biologically active ligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73596430" target="_blank" >RIV/61989592:15310/19:73596430 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S001085451930222X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S001085451930222X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2019.06.001" target="_blank" >10.1016/j.ccr.2019.06.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-platinum complexes containing releasable biologically active ligands

Popis výsledku v původním jazyce

Since the discovery of anticancer activity of cisplatin and other transition metal complexes, a lot of compounds have been reported as containing ligand(s) bearing its(their) own biological activity. Nowadays, the complexes containing releasable bioactive ligand(s), for which several terms (e.g., multi-targeted, multi-action or multi-modal) have been introduced, represent one of the hottest topics for the bioinorganic chemists. Herein we focused on rationally designed cytotoxic complexes of platinum-group metals, namely ruthenium, rhodium, palladium, osmium and iridium, which contain releasable bioactive ligand(s). Because a concept of multi-targeted complexes is based on a release and subsequent joint biological effect of multiple species, we concentrate especially on complexes whose fate under the (pseudo)physiological conditions is provably or most likely connected with a release of bioactive ligand(s)/substituent(s) and cytotoxic metal-containing species. Thus, the simultaneous action of the released species ensures various biological profits, such as higher cytotoxic activity, cytotoxicity at different cells (connected with the ability to overcome resistance) or modified processes connected with the mode of action, as compared with the initial complexes without bioactive ligand(s).

Název v anglickém jazyce

Non-platinum complexes containing releasable biologically active ligands

Popis výsledku anglicky

Since the discovery of anticancer activity of cisplatin and other transition metal complexes, a lot of compounds have been reported as containing ligand(s) bearing its(their) own biological activity. Nowadays, the complexes containing releasable bioactive ligand(s), for which several terms (e.g., multi-targeted, multi-action or multi-modal) have been introduced, represent one of the hottest topics for the bioinorganic chemists. Herein we focused on rationally designed cytotoxic complexes of platinum-group metals, namely ruthenium, rhodium, palladium, osmium and iridium, which contain releasable bioactive ligand(s). Because a concept of multi-targeted complexes is based on a release and subsequent joint biological effect of multiple species, we concentrate especially on complexes whose fate under the (pseudo)physiological conditions is provably or most likely connected with a release of bioactive ligand(s)/substituent(s) and cytotoxic metal-containing species. Thus, the simultaneous action of the released species ensures various biological profits, such as higher cytotoxic activity, cytotoxicity at different cells (connected with the ability to overcome resistance) or modified processes connected with the mode of action, as compared with the initial complexes without bioactive ligand(s).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

COORDINATION CHEMISTRY REVIEWS

ISSN

0010-8545

e-ISSN

—

Svazek periodika

395

Číslo periodika v rámci svazku

SEP

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

16

Strana od-do

130-145

Kód UT WoS článku

000474313600006

EID výsledku v databázi Scopus

2-s2.0-85066982036