Natural Biopolymeric Nanoformulations for Brain Drug Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604517" target="_blank" >RIV/61989592:15310/20:73604517 - isvavai.cz</a>

Výsledek na webu

<a href="https://obd.upol.cz/id_publ/333184403" target="_blank" >https://obd.upol.cz/id_publ/333184403</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Natural Biopolymeric Nanoformulations for Brain Drug Delivery

Popis výsledku v původním jazyce

The blood-brain barrier (BBB) prevents the passage of many drugs that target the central nervous system (CNS). The BBB represents a structure with a complex cellular organization that separates the brain parenchyma from the systemic circulation. The BBB acts not only as a mechanical barrier but also as a metabolic barrier because of the presence of numerous enzymes that are able to inactivate xenobiotics potentially harmful to the CNS. On the other hand, many drugs, such as anti-infectious drugs, antineoplastics and a number of drugs for the treatment of neurological or psychiatric diseases, have to circumvent the BBB and reach their targets in the CNS. An application of nanoparticles as drug carriers can be considered as one of the possible strategies of drug delivery to the CNS. The application of nanomaterials as drug carriers have a number of advantages, especially targeted biodistribution and controlled release and thus, increased bioavailability and decreased toxicity. Currently, various polymer materials are preferred as nanocar-riers because of their compatibility, inertness, and biodegradability. This 132contribution is focused on nanoformulations of various classes of drugs, the site of action of which is in the CNS, that were prepared using polymers of natural origin and their semisynthetic modifications representing a class of biocompatible and biodegradable carriers ensuring better therapeutic efficiency and toxicity profile of drugs.

Název v anglickém jazyce

Natural Biopolymeric Nanoformulations for Brain Drug Delivery

Popis výsledku anglicky

The blood-brain barrier (BBB) prevents the passage of many drugs that target the central nervous system (CNS). The BBB represents a structure with a complex cellular organization that separates the brain parenchyma from the systemic circulation. The BBB acts not only as a mechanical barrier but also as a metabolic barrier because of the presence of numerous enzymes that are able to inactivate xenobiotics potentially harmful to the CNS. On the other hand, many drugs, such as anti-infectious drugs, antineoplastics and a number of drugs for the treatment of neurological or psychiatric diseases, have to circumvent the BBB and reach their targets in the CNS. An application of nanoparticles as drug carriers can be considered as one of the possible strategies of drug delivery to the CNS. The application of nanomaterials as drug carriers have a number of advantages, especially targeted biodistribution and controlled release and thus, increased bioavailability and decreased toxicity. Currently, various polymer materials are preferred as nanocar-riers because of their compatibility, inertness, and biodegradability. This 132contribution is focused on nanoformulations of various classes of drugs, the site of action of which is in the CNS, that were prepared using polymers of natural origin and their semisynthetic modifications representing a class of biocompatible and biodegradable carriers ensuring better therapeutic efficiency and toxicity profile of drugs.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanocarriers for Brain Targeting

ISBN

978-0-429-46507-9

Počet stran výsledku

74

Strana od-do

131-203

Počet stran knihy

511

Název nakladatele

Apple Academic Press

Místo vydání

Oakville

Kód UT WoS kapitoly

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