Antipsoriatic natural products
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F20%3A73604951" target="_blank" >RIV/61989592:15310/20:73604951 - isvavai.cz</a>
Výsledek na webu
<a href="https://obd.upol.cz/id_publ/333184837" target="_blank" >https://obd.upol.cz/id_publ/333184837</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.armc.2020.02.005" target="_blank" >10.1016/bs.armc.2020.02.005</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antipsoriatic natural products
Popis výsledku v původním jazyce
Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.
Název v anglickém jazyce
Antipsoriatic natural products
Popis výsledku anglicky
Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
—
OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Annual Reports in Medicinal Chemistry
ISBN
978-0-12-821019-2
Počet stran výsledku
29
Strana od-do
297-325
Počet stran knihy
515
Název nakladatele
Academic Press
Místo vydání
London
Kód UT WoS kapitoly
—