Antipsoriatic natural products

Kód výsledku v IS VaVaI

RIV/61989592:15310/20:73604951 - isvavai.cz

Výsledek na webu

https://obd.upol.cz/id_publ/333184837

DOI - Digital Object Identifier

10.1016/bs.armc.2020.02.005

Jazyk výsledku

angličtina

Název v původním jazyce

Antipsoriatic natural products

Popis výsledku v původním jazyce

Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.

Název v anglickém jazyce

Antipsoriatic natural products

Popis výsledku anglicky

Psoriasis, a chronic inflammatory skin disease, is characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes, inflammatory infiltration and increased skin vascularization. Despite their clinical efficacy, the current antipsoriatic drugs have a poor safety profile as they are responsible for a wide range of side effects such as skin irritation, teratogenicity, hepatotoxicity, nephrotoxicity, myelosuppression and even disease rebound after cessation. Recent studies highlighted that natural products derived from plants and marine organisms contain scaffold structures that can be exploited for the development of novel antipsoriatic drugs. Pure constituents isolated from plants and marine sponges, belonging to different chemical classes: alkaloids, cyclopeptides, flavonoids, furanocoumarins, organic acid derivatives, polyphenols, sphingolipids and terpenoids, and their analogues have been investigated for their antipsoriatic activity in different experimental models. The chapter reviews natural products derived from plants and marine organisms and their analogues which, based on their bioactivities and virtual screening studies, appear to be potential candidates for the development of novel antipsoriatic drugs.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30107 - Medicinal chemistry

Projekt

EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Annual Reports in Medicinal Chemistry

ISBN

978-0-12-821019-2

Počet stran výsledku

29

Strana od-do

297-325

Počet stran knihy

515

Název nakladatele

Academic Press

Místo vydání

London

Kód UT WoS kapitoly

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