Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F21%3A73609419" target="_blank" >RIV/61989592:15310/21:73609419 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0010854520305075" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010854520305075</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2020.213690" target="_blank" >10.1016/j.ccr.2020.213690</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

Popis výsledku v původním jazyce

The development of multinuclear homometallic biologically active complexes is attractive for modern bioinorganic chemistry, because this concept offers a multiplication of the therapeutic effect of mononuclear complexes and a variation of mechanism of action (MoA). In addition to homometallic complexes containing two or more metal centres of the same element, heterometallic complexes combine various metal centres within one complex species. Since MoA of anticancer transition metal complexes is usually metal-specific, a combination of different metals affecting various processes in the exposed cells should ensure a unique MoA of such heterometallic complexes. This review is focused on multinuclear complexes derived from half-sandwich ruthenium(II), rhodium (III), osmium(II) or iridium(III) arene moieties, covalently bridged with one or more metal-based species within a homo- or heterometallic entities. The overviewed complexes are categorized according the element in the metal-arene moiety and types of the conjugated species. In most cases, complexes were studied for their cytotoxicity, fewer compounds were tested for their antimicrobial activity. Special attention was paid to the comparison of structurally similar analogues differing in the number or type of metal centres.

Název v anglickém jazyce

Multinuclear biologically active Ru, Rh, Os and Ir arene complexes

Popis výsledku anglicky

The development of multinuclear homometallic biologically active complexes is attractive for modern bioinorganic chemistry, because this concept offers a multiplication of the therapeutic effect of mononuclear complexes and a variation of mechanism of action (MoA). In addition to homometallic complexes containing two or more metal centres of the same element, heterometallic complexes combine various metal centres within one complex species. Since MoA of anticancer transition metal complexes is usually metal-specific, a combination of different metals affecting various processes in the exposed cells should ensure a unique MoA of such heterometallic complexes. This review is focused on multinuclear complexes derived from half-sandwich ruthenium(II), rhodium (III), osmium(II) or iridium(III) arene moieties, covalently bridged with one or more metal-based species within a homo- or heterometallic entities. The overviewed complexes are categorized according the element in the metal-arene moiety and types of the conjugated species. In most cases, complexes were studied for their cytotoxicity, fewer compounds were tested for their antimicrobial activity. Special attention was paid to the comparison of structurally similar analogues differing in the number or type of metal centres.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Coordination Chemistry Reviews

ISSN

0010-8545

e-ISSN

—

Svazek periodika

431

Číslo periodika v rámci svazku

MAR

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

47

Strana od-do

"213690-1"-"213690-47"

Kód UT WoS článku

000635556300002

EID výsledku v databázi Scopus

2-s2.0-85097764720