Controlled nucleation of crystallization process as an efficient tool to tune the properties of corticosteroid API

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73612814" target="_blank" >RIV/61989592:15310/22:73612814 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/22:73612814

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0032591022002285" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022002285</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2022.117334" target="_blank" >10.1016/j.powtec.2022.117334</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Controlled nucleation of crystallization process as an efficient tool to tune the properties of corticosteroid API

Popis výsledku v původním jazyce

Crystallization as one of the final steps in the industrial production of active pharmaceutical ingredients (APIs) significantly influences their physicochemical and rheological properties. Different crystallization procedures including antisolvent crystallization, seeding crystallization, crystallization with templates and sonocrystallization were utilized for the production of corticosteroid APIs-fluticasone propionate. The final crystalline APIs obtained by individual crystallization procedures were characterized by a wide range of characterization techniques. We show that nucleation is a critical step that significantly affects APIs&apos; properties. Controlled nucleation thus represents an easy method for managing these properties. Well-designed nucleation yields to crystalline products, which does not necessitate any post-processing including, e.g., micronization. These findings can be widely applied to the production of API with targeted properties.

Název v anglickém jazyce

Controlled nucleation of crystallization process as an efficient tool to tune the properties of corticosteroid API

Popis výsledku anglicky

Crystallization as one of the final steps in the industrial production of active pharmaceutical ingredients (APIs) significantly influences their physicochemical and rheological properties. Different crystallization procedures including antisolvent crystallization, seeding crystallization, crystallization with templates and sonocrystallization were utilized for the production of corticosteroid APIs-fluticasone propionate. The final crystalline APIs obtained by individual crystallization procedures were characterized by a wide range of characterization techniques. We show that nucleation is a critical step that significantly affects APIs&apos; properties. Controlled nucleation thus represents an easy method for managing these properties. Well-designed nucleation yields to crystalline products, which does not necessitate any post-processing including, e.g., micronization. These findings can be widely applied to the production of API with targeted properties.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

POWDER TECHNOLOGY

ISSN

0032-5910

e-ISSN

1873-328X

Svazek periodika

402

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

"17334-1"-117334

Kód UT WoS článku

000793463500010

EID výsledku v databázi Scopus

2-s2.0-85128166241