Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73626967" target="_blank" >RIV/61989592:15310/25:73626967 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0300908424002025" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300908424002025</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2024.09.002" target="_blank" >10.1016/j.biochi.2024.09.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Popis výsledku v původním jazyce

Natural products are widely used in different aspects of our lives – from household cleaners and food production, via cosmetics and aromatherapy, to both alternative and traditional medicine. In our research group, we have recently described several monoterpenoids with potential in the antiviral and anticancer therapy by allosteric targeting of aryl hydrocarbon receptor (AhR). Prior to any practical application, biological effects on human organism must be taken in concern. This review article is focused on the biological effects of 5 monoterpenoids on the human health previously identified as AhR antagonists with a therapeutic potential as antiviral and anticancer agents. We have thoroughly described cytotoxic, anti-inflammatory, anti-proliferative, and anticancer effects, as well as known interactions with nuclear receptors. As clearly demonstrated, monoterpenoids in general represent almost an inexhaustible reservoir of natural compounds possessing the ability to influence, modulate and improve human health.

Název v anglickém jazyce

Dietary monoterpenoids and human health: Unlocking the potential for therapeutic use

Popis výsledku anglicky

Natural products are widely used in different aspects of our lives – from household cleaners and food production, via cosmetics and aromatherapy, to both alternative and traditional medicine. In our research group, we have recently described several monoterpenoids with potential in the antiviral and anticancer therapy by allosteric targeting of aryl hydrocarbon receptor (AhR). Prior to any practical application, biological effects on human organism must be taken in concern. This review article is focused on the biological effects of 5 monoterpenoids on the human health previously identified as AhR antagonists with a therapeutic potential as antiviral and anticancer agents. We have thoroughly described cytotoxic, anti-inflammatory, anti-proliferative, and anticancer effects, as well as known interactions with nuclear receptors. As clearly demonstrated, monoterpenoids in general represent almost an inexhaustible reservoir of natural compounds possessing the ability to influence, modulate and improve human health.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA23-04662S" target="_blank" >GA23-04662S: Monoterpenoidy jako nová třída negativních alosterických modulátorů aryl uhlovodíkového receptoru v terapii kolorektálního karcinomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOCHIMIE

ISSN

0300-9084

e-ISSN

1638-6183

Svazek periodika

228

Číslo periodika v rámci svazku

JAN

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

12

Strana od-do

89-100

Kód UT WoS článku

001401359600001

EID výsledku v databázi Scopus

2-s2.0-85204397465