Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73633635" target="_blank" >RIV/61989592:15310/25:73633635 - isvavai.cz</a>

Výsledek na webu

<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.70259?getft_integrator=clarivate&src=getftr&utm_source=clarivate" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.70259?getft_integrator=clarivate&src=getftr&utm_source=clarivate</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.70259" target="_blank" >10.1002/jssc.70259</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis

Popis výsledku v původním jazyce

The increasing use of engineered nanoparticles (NPs) in consumer and biomedical products has raised concern over their potential accumulation, transformation, and toxicity in biological systems. Accurate analytical methods are essential to detect, characterize, and quantify NPs in complex biological matrices. Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as a leading technique due to its high sensitivity, elemental selectivity, and quantitative capabilities. This review critically evaluates recent advances (from January 2020 onward) in ICP-MS-based methods for analysis of NPs in biological samples. Two main strategies are discussed: single-particle ICP-MS (spICP-MS) and hyphenated techniques coupled to ICP-MS. spICP-MS allows direct determination of particle size, concentration, and metal content at environmentally relevant levels. It is the most widely used approach and is therefore examined in greater detail, with attention to extraction procedures, particle types, sample matrices, and inherent limitations. Advances in laser ablation spICP-MS for tissue imaging and spatially resolved NPs detection are also covered. Methods using hyphenated techniques, such as hydrodynamic chromatography, size-exclusion chromatography, capillary electrophoresis, Taylor dispersion analysis, and field-flow fractionation, are increasingly employed to address limitations spICP-MS. These approaches can provide enhanced insight into particle size distributions, aggregation behavior, and interactions with complex sample matrices. This review offers a comparative evaluation of both single-particle and hyphenated methods, discussing their respective advantages and limitations. Emphasis is placed on the complementarity of these techniques and how their combined use can offer a more complete understanding of NPs&apos; fate in biological systems.

Název v anglickém jazyce

Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis

Popis výsledku anglicky

The increasing use of engineered nanoparticles (NPs) in consumer and biomedical products has raised concern over their potential accumulation, transformation, and toxicity in biological systems. Accurate analytical methods are essential to detect, characterize, and quantify NPs in complex biological matrices. Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as a leading technique due to its high sensitivity, elemental selectivity, and quantitative capabilities. This review critically evaluates recent advances (from January 2020 onward) in ICP-MS-based methods for analysis of NPs in biological samples. Two main strategies are discussed: single-particle ICP-MS (spICP-MS) and hyphenated techniques coupled to ICP-MS. spICP-MS allows direct determination of particle size, concentration, and metal content at environmentally relevant levels. It is the most widely used approach and is therefore examined in greater detail, with attention to extraction procedures, particle types, sample matrices, and inherent limitations. Advances in laser ablation spICP-MS for tissue imaging and spatially resolved NPs detection are also covered. Methods using hyphenated techniques, such as hydrodynamic chromatography, size-exclusion chromatography, capillary electrophoresis, Taylor dispersion analysis, and field-flow fractionation, are increasingly employed to address limitations spICP-MS. These approaches can provide enhanced insight into particle size distributions, aggregation behavior, and interactions with complex sample matrices. This review offers a comparative evaluation of both single-particle and hyphenated methods, discussing their respective advantages and limitations. Emphasis is placed on the complementarity of these techniques and how their combined use can offer a more complete understanding of NPs&apos; fate in biological systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF SEPARATION SCIENCE

ISSN

1615-9306

e-ISSN

1615-9314

Svazek periodika

48

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

23

Strana od-do

"e70259-1"-"e70259-23"

Kód UT WoS článku

001568594000001

EID výsledku v databázi Scopus

2-s2.0-105015493996