Enhanced immune response and antimicrobial activity in honey bees (Apis mellifera) following application of oxalic acid-glycerine strips

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73634386" target="_blank" >RIV/61989592:15310/25:73634386 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/25:102722 RIV/00216224:14310/25:00144705

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0048357525000665" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0048357525000665</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pestbp.2025.106353" target="_blank" >10.1016/j.pestbp.2025.106353</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enhanced immune response and antimicrobial activity in honey bees (Apis mellifera) following application of oxalic acid-glycerine strips

Popis výsledku v původním jazyce

Bee health is influenced by multiple factors, including nutrition, immunity, and parasitic pressures. Since the spread of Varroa destructor, overwintering survival has significantly declined, making it one of the most serious threats to honey bee (Apis mellifera L.) populations worldwide. Natural acaricides, such as oxalic acid (OA), are widely employed for managing Varroa mites; however, their pharmacodynamics, particularly their impacts on honey bee physiology and immunity, remain insufficiently understood. We studied effects of oxalic acid on honey bee workers. The study compared three treatments: flumethrin, OA-glycerine strips (OA-G), and OA trickling (OA-T). Twelve colonies were divided into four groups, with samples collected at five time points (0, 24, 48, 72, and 192 h). Physiological changes were assessed through markers of oxidative stress, longevity, and immune parameters. Exposure to oxalic acid via glycerine strips induced a humoral immune response in adult bees. The antimicrobial activity of hemolymph and levels of antimicrobial peptides (abaecin, apidaecin, defensin, and hymenoptaecin) were elevated between 48 and 192 h after OA-G treatment compared to the control group. In contrast, these parameters were not influenced by OA-T or flumethrin treatment. These findings suggest that OA- G strips activate the honey bee&apos;s immune system, providing insights into broader implications of OA use in beekeeping. It is crucial to determine whether the activation of humoral immune systems has positive or negative effects, as well as to develop standardized and reliable treatment protocols that ensure both- health of colonies and their effectiveness in controlling Varroa mite infestations.

Název v anglickém jazyce

Enhanced immune response and antimicrobial activity in honey bees (Apis mellifera) following application of oxalic acid-glycerine strips

Popis výsledku anglicky

Bee health is influenced by multiple factors, including nutrition, immunity, and parasitic pressures. Since the spread of Varroa destructor, overwintering survival has significantly declined, making it one of the most serious threats to honey bee (Apis mellifera L.) populations worldwide. Natural acaricides, such as oxalic acid (OA), are widely employed for managing Varroa mites; however, their pharmacodynamics, particularly their impacts on honey bee physiology and immunity, remain insufficiently understood. We studied effects of oxalic acid on honey bee workers. The study compared three treatments: flumethrin, OA-glycerine strips (OA-G), and OA trickling (OA-T). Twelve colonies were divided into four groups, with samples collected at five time points (0, 24, 48, 72, and 192 h). Physiological changes were assessed through markers of oxidative stress, longevity, and immune parameters. Exposure to oxalic acid via glycerine strips induced a humoral immune response in adult bees. The antimicrobial activity of hemolymph and levels of antimicrobial peptides (abaecin, apidaecin, defensin, and hymenoptaecin) were elevated between 48 and 192 h after OA-G treatment compared to the control group. In contrast, these parameters were not influenced by OA-T or flumethrin treatment. These findings suggest that OA- G strips activate the honey bee&apos;s immune system, providing insights into broader implications of OA use in beekeeping. It is crucial to determine whether the activation of humoral immune systems has positive or negative effects, as well as to develop standardized and reliable treatment protocols that ensure both- health of colonies and their effectiveness in controlling Varroa mite infestations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10616 - Entomology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pesticide Biochemistry and Physiology

ISSN

0048-3575

e-ISSN

1095-9939

Svazek periodika

209

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

"106353-1"-"106353-11"

Kód UT WoS článku

001440631400001

EID výsledku v databázi Scopus

2-s2.0-85219009132