Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73634953" target="_blank" >RIV/61989592:15310/25:73634953 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/1422-0067/26/5/2057" target="_blank" >https://www.mdpi.com/1422-0067/26/5/2057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms26052057" target="_blank" >10.3390/ijms26052057</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering

Popis výsledku v původním jazyce

This study investigates the physicochemical properties of hydrogels based on PVA and PVP crosslinked with PEGDA, focusing on their swelling capacity, surface roughness, incubation behavior, and structural modifications upon bioactive component incorporation. Swelling analysis demonstrated that the amount and molecular weight of PEGDA significantly influences the hydrogels’ sorption properties, with the highest swelling coefficient observed for samples with 2 mL PEGDA (575 g/mol) due to a looser network structure, while the lowest was recorded for 2.5 mL PEGDA (700 g/mol), indicatinga denser network. Surface roughness analysis revealed that increasing the crosslinker amount led to higher roughness both before and after incubation, with samples containing 575 g/mol PEGDA being more susceptible to structural changes in an incubation environment. FT-IR spectroscopy confirmed the presence of characteristic functional groups, providing insight into the chemical stability and hydration properties of the hydrogels. Modification with a bioactive mixture (glucosamine, chondroitin, and MSM) was confirmed by spectral analysis, indicating successful integration without compromising the hydrogel matrix. The modified hydrogels demonstrated potential applications in regenerative medicine, particularly for joint disease treatment and cartilage tissue repair.

Název v anglickém jazyce

Evaluation of Physicochemical Properties of Polymeric Systems for Potential Applications in Cartilage Tissue Engineering

Popis výsledku anglicky

This study investigates the physicochemical properties of hydrogels based on PVA and PVP crosslinked with PEGDA, focusing on their swelling capacity, surface roughness, incubation behavior, and structural modifications upon bioactive component incorporation. Swelling analysis demonstrated that the amount and molecular weight of PEGDA significantly influences the hydrogels’ sorption properties, with the highest swelling coefficient observed for samples with 2 mL PEGDA (575 g/mol) due to a looser network structure, while the lowest was recorded for 2.5 mL PEGDA (700 g/mol), indicatinga denser network. Surface roughness analysis revealed that increasing the crosslinker amount led to higher roughness both before and after incubation, with samples containing 575 g/mol PEGDA being more susceptible to structural changes in an incubation environment. FT-IR spectroscopy confirmed the presence of characteristic functional groups, providing insight into the chemical stability and hydration properties of the hydrogels. Modification with a bioactive mixture (glucosamine, chondroitin, and MSM) was confirmed by spectral analysis, indicating successful integration without compromising the hydrogel matrix. The modified hydrogels demonstrated potential applications in regenerative medicine, particularly for joint disease treatment and cartilage tissue repair.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN

1422-0067

e-ISSN

1422-0067

Svazek periodika

26

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

"2057-1"-"2057-19"

Kód UT WoS článku

001442676500001

EID výsledku v databázi Scopus

2-s2.0-86000552567