Comparative Review of Cold Maceration and Decoction Methods in Shaping the Antihypertensive Efficacy of Egyptian Hibiscus sabdariffa L.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F25%3A73635176" target="_blank" >RIV/61989592:15310/25:73635176 - isvavai.cz</a>

Výsledek na webu

<a href="https://media.sciltp.com/articles/2512002621/2512002621.pdf" target="_blank" >https://media.sciltp.com/articles/2512002621/2512002621.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.53941/jmnp.2025.100027" target="_blank" >10.53941/jmnp.2025.100027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative Review of Cold Maceration and Decoction Methods in Shaping the Antihypertensive Efficacy of Egyptian Hibiscus sabdariffa L.

Popis výsledku v původním jazyce

Hypertension remains a leading global health challenge, particularly in low- and middle-income countries where non-pharmacological interventions are increasingly sought. Hibiscus sabdariffa L., commonly known as roselle or sour tea, has gained attention for its antihypertensive properties, largely attributed to bioactive compounds such as anthocyanins, phenolic acids, and flavonoids. This review evaluates the influence of extraction methods. Cold maceration and hot decoction shape the phytochemical profile and antihypertensive efficacy of H. sabdariffa in distinct ways. Evidence from in vitro, in vivo, and clinical studies indicates that both extraction methods yield beneficial compounds. Hot aqueous extraction consistently enhances phenolic content and demonstrates superior blood pressure-lowering effects. Mechanisms include angiotensin-converting enzyme (ACE) inhibition, nitric oxide modulation, and vascular histology restoration. Cold extraction better preserves anthocyanins, which are strongly linked to antioxidant and cardioprotective outcomes, though the overall hypotensive impact is comparatively moderate. The findings suggest that hot extraction is preferable for therapeutic applications, while cold extraction may be suitable for functional beverages aimed at maximising anthocyanin content. Future research should optimise extraction conditions to balance phytochemical stability and pharmacological efficacy. Clinical trials are needed to validate dosage forms, long-term safety, and potential interactions with conventional antihypertensive drugs. This review evaluates how extraction methods shape the antihypertensive efficacy of Egyptian H. sabdariffa, guiding its integration into affordable cardiovascular care.

Název v anglickém jazyce

Comparative Review of Cold Maceration and Decoction Methods in Shaping the Antihypertensive Efficacy of Egyptian Hibiscus sabdariffa L.

Popis výsledku anglicky

Hypertension remains a leading global health challenge, particularly in low- and middle-income countries where non-pharmacological interventions are increasingly sought. Hibiscus sabdariffa L., commonly known as roselle or sour tea, has gained attention for its antihypertensive properties, largely attributed to bioactive compounds such as anthocyanins, phenolic acids, and flavonoids. This review evaluates the influence of extraction methods. Cold maceration and hot decoction shape the phytochemical profile and antihypertensive efficacy of H. sabdariffa in distinct ways. Evidence from in vitro, in vivo, and clinical studies indicates that both extraction methods yield beneficial compounds. Hot aqueous extraction consistently enhances phenolic content and demonstrates superior blood pressure-lowering effects. Mechanisms include angiotensin-converting enzyme (ACE) inhibition, nitric oxide modulation, and vascular histology restoration. Cold extraction better preserves anthocyanins, which are strongly linked to antioxidant and cardioprotective outcomes, though the overall hypotensive impact is comparatively moderate. The findings suggest that hot extraction is preferable for therapeutic applications, while cold extraction may be suitable for functional beverages aimed at maximising anthocyanin content. Future research should optimise extraction conditions to balance phytochemical stability and pharmacological efficacy. Clinical trials are needed to validate dosage forms, long-term safety, and potential interactions with conventional antihypertensive drugs. This review evaluates how extraction methods shape the antihypertensive efficacy of Egyptian H. sabdariffa, guiding its integration into affordable cardiovascular care.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10611 - Plant sciences, botany

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medicinal Natural Products

ISSN

2982-1975

e-ISSN

—

Svazek periodika

2

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

AU - Austrálie

Počet stran výsledku

9

Strana od-do

"100027-1"-"100027-9"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

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