Structural determination of N6-isopentenyladenine decomposition products during acid hydrolysis

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Structural determination of N6-isopentenyladenine decomposition products during acid hydrolysis

Popis výsledku v původním jazyce

Novel products of N6-isopentenyladenine (IPA) transformation in 0.01, 0.1 and 2M HCl solutions have been characterized by single crystal X-ray analysis. IPA is converted to compounds of various structures depending on physical conditions such are temperature, pH medium and time. IPA is simply protonated in 0.01M HCl. The main structural changes arise in 0.1M HCl (L1) while the greatest ones have been observed in 2M HCl, where (H2+L2)Cl2.2H2O formed {i.e. 5-(4,4-dimethyl-1,3,5,6-hexahydropyrimidinium-2-yl)-1,3H-imidazolium-4-yl-amine dichloride dihydrate}. The coordination ability of the acid hydrolysis various organic products towards zinc(II) chloride has also been examined. The following complexes have been formed and their structures have been determided: [ZnCl3(H+IPA)], [Zn3Cl8(H+L1)2] and (H2+L2)[ZnCl4]. The results of biological activity testing (cytotoxicity for selected human tumor cell lines) of the prepared compounds will be also presented.

Název v anglickém jazyce

Structural determination of N6-isopentenyladenine decomposition products during acid hydrolysis

Popis výsledku anglicky

Novel products of N6-isopentenyladenine (IPA) transformation in 0.01, 0.1 and 2M HCl solutions have been characterized by single crystal X-ray analysis. IPA is converted to compounds of various structures depending on physical conditions such are temperature, pH medium and time. IPA is simply protonated in 0.01M HCl. The main structural changes arise in 0.1M HCl (L1) while the greatest ones have been observed in 2M HCl, where (H2+L2)Cl2.2H2O formed {i.e. 5-(4,4-dimethyl-1,3,5,6-hexahydropyrimidinium-2-yl)-1,3H-imidazolium-4-yl-amine dichloride dihydrate}. The coordination ability of the acid hydrolysis various organic products towards zinc(II) chloride has also been examined. The following complexes have been formed and their structures have been determided: [ZnCl3(H+IPA)], [Zn3Cl8(H+L1)2] and (H2+L2)[ZnCl4]. The results of biological activity testing (cytotoxicity for selected human tumor cell lines) of the prepared compounds will be also presented.

Druh

D - Stať ve sborníku

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

21st European Crystallographic Meeting, Durban, South Africa, 24-29 August 2003

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

400

Strana od-do

229

Název nakladatele

South African Crystallographic Society

Místo vydání

Durban, South Africa

Místo konání akce

Durban, South Africa

Datum konání akce

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Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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