An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F21%3A73607326" target="_blank" >RIV/61989592:15640/21:73607326 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2021/GC/D0GC02719G" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/GC/D0GC02719G</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d0gc02719g" target="_blank" >10.1039/d0gc02719g</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

Popis výsledku v původním jazyce

The design of wound dressing hydrogels is of utmost importance in healthcare with desired remedial effects, self-healing ability, cell affinity, and appropriate mechanical properties, particularly for healing skin wounds; excellent wound tissue adhesiveness is imperative. Here, an ultra-tough and self-healable double-network (DN) hydrogel is designed based on salep/poly(vinyl alcohol) that is endowed with superior tissue adhesiveness and cell affinity as demonstrated for critical and burn wound healing in rats. The self-healing capability of the hydrogel is attained via hydrogen bonds and Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) chains (OSEA network). The interaction of hydroxyl groups of the poly(vinyl alcohol) (PVA) network effectively facilitates to create a stable mechanical structure and endow self-healing ability. The ensuing novel hydrogel is endowed with excellent self-healing ability, high mechanical strength (Young&apos;s modulus of up to 14 kPa; high fracture energy of up to 90 kJ m(-3); compressive stress of 400 kPa), good tissue adhesiveness (up to 48 N m(-1) adhesive strength), and superior therapeutic properties (cell viability of A375 cells &gt;80%; remarkable healing of &gt;60% in 14 and &gt;98% in 21 days). The macroscopic evaluation revealed healing &gt;80% in 14 days and 100% in 21 days that is achieved by combining both networks in a single system along with Arnebia extract and Ag nanoparticles (Ag NPs) in green media. In vitro and in vivo tests affirmed that the PVA/OSEA DN hydrogel could be an excellent candidate for skin tissue regeneration in medical applications.

Název v anglickém jazyce

An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

Popis výsledku anglicky

The design of wound dressing hydrogels is of utmost importance in healthcare with desired remedial effects, self-healing ability, cell affinity, and appropriate mechanical properties, particularly for healing skin wounds; excellent wound tissue adhesiveness is imperative. Here, an ultra-tough and self-healable double-network (DN) hydrogel is designed based on salep/poly(vinyl alcohol) that is endowed with superior tissue adhesiveness and cell affinity as demonstrated for critical and burn wound healing in rats. The self-healing capability of the hydrogel is attained via hydrogen bonds and Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) chains (OSEA network). The interaction of hydroxyl groups of the poly(vinyl alcohol) (PVA) network effectively facilitates to create a stable mechanical structure and endow self-healing ability. The ensuing novel hydrogel is endowed with excellent self-healing ability, high mechanical strength (Young&apos;s modulus of up to 14 kPa; high fracture energy of up to 90 kJ m(-3); compressive stress of 400 kPa), good tissue adhesiveness (up to 48 N m(-1) adhesive strength), and superior therapeutic properties (cell viability of A375 cells &gt;80%; remarkable healing of &gt;60% in 14 and &gt;98% in 21 days). The macroscopic evaluation revealed healing &gt;80% in 14 days and 100% in 21 days that is achieved by combining both networks in a single system along with Arnebia extract and Ag nanoparticles (Ag NPs) in green media. In vitro and in vivo tests affirmed that the PVA/OSEA DN hydrogel could be an excellent candidate for skin tissue regeneration in medical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

GREEN CHEMISTRY

ISSN

1463-9262

e-ISSN

—

Svazek periodika

2021

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

1312-1329

Kód UT WoS článku

000618044800023

EID výsledku v databázi Scopus

2-s2.0-85101082097