Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F24%3A73625376" target="_blank" >RIV/61989592:15640/24:73625376 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/24:00375941

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.jpclett.4c00164" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jpclett.4c00164</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jpclett.4c00164" target="_blank" >10.1021/acs.jpclett.4c00164</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator

Popis výsledku v původním jazyce

Molecular structural elucidation can be accomplished by different techniques, such as nuclear magnetic resonance or X-ray diffraction. However, the former does not give information about the three-dimensional atomic arrangement, and the latter needs crystallizable solid samples. An alternative is direct, real-space visualization of the molecules by cryogenic scanning tunneling microscopy (STM). This technique is usually limited to thermally robust molecules because an annealing step is required for sample deposition. A landmark development has been the coupling of STM with electrospray deposition (ESD), which smooths the process and widens the scope of the visualization technique. In this work, we present the on-surface characterization of air-, light-, and temperature-sensitive rhamnopolyene with relevance in molecular biology. Supported by theoretical calculations, we characterize two isomers of this flexible molecule, confirming the potential of the technique to inspect labile, non-crystallizable compounds.

Název v anglickém jazyce

Single-Molecule Identification of the Isomers of a Lipidic Antibody Activator

Popis výsledku anglicky

Molecular structural elucidation can be accomplished by different techniques, such as nuclear magnetic resonance or X-ray diffraction. However, the former does not give information about the three-dimensional atomic arrangement, and the latter needs crystallizable solid samples. An alternative is direct, real-space visualization of the molecules by cryogenic scanning tunneling microscopy (STM). This technique is usually limited to thermally robust molecules because an annealing step is required for sample deposition. A landmark development has been the coupling of STM with electrospray deposition (ESD), which smooths the process and widens the scope of the visualization technique. In this work, we present the on-surface characterization of air-, light-, and temperature-sensitive rhamnopolyene with relevance in molecular biology. Supported by theoretical calculations, we characterize two isomers of this flexible molecule, confirming the potential of the technique to inspect labile, non-crystallizable compounds.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10301 - Atomic, molecular and chemical physics (physics of atoms and molecules including collision, interaction with radiation, magnetic resonances, Mössbauer effect)

Projekt

<a href="/cs/project/GM23-06781M" target="_blank" >GM23-06781M: Řízení a vizualizace delokalizace náboje v atomárním měřítku v molekulárních nanomodelech pohlcujících světlo</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physical Chemistry Letters

ISSN

1948-7185

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

27

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"6935 "- 6942

Kód UT WoS článku

001258147800001

EID výsledku v databázi Scopus

2-s2.0-85197048908