Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73629834" target="_blank" >RIV/61989592:15640/25:73629834 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10497361 RIV/61989592:15110/25:73629834 RIV/61989592:15310/25:73629834 RIV/61989100:27640/25:10257637

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2666523925000224" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2666523925000224</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsadv.2025.100713" target="_blank" >10.1016/j.apsadv.2025.100713</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Popis výsledku v původním jazyce

Plasmonic titanium nitride (TiN) nanoparticles are emerging nanomaterials possessing several orders of magnitude higher absorption cross section, but also exhibit higher photostability compared to conventional photosenzitizers. In the recent years, TiN has emerged as a highly effective electrocatalytic and environmentally friendly material with good biocompatibility. Its unique physicochemical properties and cost-effectiveness are essential for wide utilization in biomedicine. However, the effect of morphology of TiN on the photothermal therapy (PTT) efficiency has not been studied yet. Here, TiN nanocrystals of two precisely defined morphologies - nanobars and nanospheres - were prepared by unique pseudomorphic conversion of TiO2 nanowires and nanospheres via nitridation at 800 °C. Due to their multiple plasmonic resonances, the resulting materials show broad optical absorption spanning the entire solar spectrum and biological window including the NIR-I (750 – 1000 nm) and NIR-II (1000 – 1350 nm). Using low power illumination 318 mW/cm2 and NIR LED irradiation 940 nm, we observed a morphology-dependent PTT bioactivity, with the TiN nanobars being more efficient in cancer HeLa cells killing, while nanospheres showed higher antimicrobial activity toward Staphylococcus aureus and Escherichia coli bacteria strains. Moreover, acute and long-term in vitro biocompatibility together with in vivo monitoring of biodistribution showing enhanced permeability and retention (EPR) effect were confirmed by photoacoustic (PA) imaging in tumor bearing mice (C57BL/6J albino, EL4 lymphoma cell line). Thus, both TiN morphologies - nanobars and nanospheres are promising candidates in theranostic application via PTT therapy and PA imaging.

Název v anglickém jazyce

Morphology-dependent near-infrared photothermal activity of plasmonic TiN nanobars and nanospheres for anticancer, antibacterial therapy and deep in vivo photoacoustic imaging

Popis výsledku anglicky

Plasmonic titanium nitride (TiN) nanoparticles are emerging nanomaterials possessing several orders of magnitude higher absorption cross section, but also exhibit higher photostability compared to conventional photosenzitizers. In the recent years, TiN has emerged as a highly effective electrocatalytic and environmentally friendly material with good biocompatibility. Its unique physicochemical properties and cost-effectiveness are essential for wide utilization in biomedicine. However, the effect of morphology of TiN on the photothermal therapy (PTT) efficiency has not been studied yet. Here, TiN nanocrystals of two precisely defined morphologies - nanobars and nanospheres - were prepared by unique pseudomorphic conversion of TiO2 nanowires and nanospheres via nitridation at 800 °C. Due to their multiple plasmonic resonances, the resulting materials show broad optical absorption spanning the entire solar spectrum and biological window including the NIR-I (750 – 1000 nm) and NIR-II (1000 – 1350 nm). Using low power illumination 318 mW/cm2 and NIR LED irradiation 940 nm, we observed a morphology-dependent PTT bioactivity, with the TiN nanobars being more efficient in cancer HeLa cells killing, while nanospheres showed higher antimicrobial activity toward Staphylococcus aureus and Escherichia coli bacteria strains. Moreover, acute and long-term in vitro biocompatibility together with in vivo monitoring of biodistribution showing enhanced permeability and retention (EPR) effect were confirmed by photoacoustic (PA) imaging in tumor bearing mice (C57BL/6J albino, EL4 lymphoma cell line). Thus, both TiN morphologies - nanobars and nanospheres are promising candidates in theranostic application via PTT therapy and PA imaging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

APPLIED SURFACE SCIENCE ADVANCES

ISSN

2666-5239

e-ISSN

2666-5239

Svazek periodika

26

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

nestránkováno

Kód UT WoS článku

001430143100001

EID výsledku v databázi Scopus

2-s2.0-85217977590