Light Irradiation of N-Doped Graphene Acid: Metal-Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F25%3A73630585" target="_blank" >RIV/61989592:15640/25:73630585 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27640/25:10257640

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/eom2.70009" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/eom2.70009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/eom2.70009" target="_blank" >10.1002/eom2.70009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Light Irradiation of N-Doped Graphene Acid: Metal-Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action

Popis výsledku v původním jazyce

The increasing emergence of antimicrobial resistance and the development of new infective viral strains represent a constantly growing threat. Metal-based nanomaterials have emerged as promising tools in the fight against bacterial and viral infections; however, the release of metal nanoparticles/ions in clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use in antimicrobial treatment. Moreover, the metal-based nanoparticles possess predominantly antibacterial effects, while their antiviral efficiency remains controversial. Thus, the development of metal-free strategies enabling combined antibacterial/antiviral properties is a significant challenge. Here, we report a strategy based on light irradiation of nitrogen-doped graphene acid (NGA) possessing dual photothermal and photodynamic modes of action. The antimicrobial activity is activated through a clinically approved near-infrared (NIR) light source, and both viral and bacterial spreading can be hampered on the coating irradiation on a scale of minutes (5 to 10 min). The developed metal-free strategy reduced 90.9% and 99.99% for S. aureus and P. aeruginosa, respectively, as well as 99.97% for murine hepatitis virus. Importantly, this research represents a significant advancement in the development of safe, metal-free, and effective antimicrobial treatments. NGA coatings are safe for skin, showing no sensitization or irritation, and offer significant potential for advanced antimicrobial treatments.

Název v anglickém jazyce

Light Irradiation of N-Doped Graphene Acid: Metal-Free Strategy Toward Antibacterial and Antiviral Coatings With Dual Modes of Action

Popis výsledku anglicky

The increasing emergence of antimicrobial resistance and the development of new infective viral strains represent a constantly growing threat. Metal-based nanomaterials have emerged as promising tools in the fight against bacterial and viral infections; however, the release of metal nanoparticles/ions in clinical applications may cause undesired side effects (allergies, systemic toxicity), reducing their practical use in antimicrobial treatment. Moreover, the metal-based nanoparticles possess predominantly antibacterial effects, while their antiviral efficiency remains controversial. Thus, the development of metal-free strategies enabling combined antibacterial/antiviral properties is a significant challenge. Here, we report a strategy based on light irradiation of nitrogen-doped graphene acid (NGA) possessing dual photothermal and photodynamic modes of action. The antimicrobial activity is activated through a clinically approved near-infrared (NIR) light source, and both viral and bacterial spreading can be hampered on the coating irradiation on a scale of minutes (5 to 10 min). The developed metal-free strategy reduced 90.9% and 99.99% for S. aureus and P. aeruginosa, respectively, as well as 99.97% for murine hepatitis virus. Importantly, this research represents a significant advancement in the development of safe, metal-free, and effective antimicrobial treatments. NGA coatings are safe for skin, showing no sensitization or irritation, and offer significant potential for advanced antimicrobial treatments.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/EH22_008%2F0004587" target="_blank" >EH22_008/0004587: Technologie za hranicí nanosvěta</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ECOMAT

ISSN

2567-3173

e-ISSN

2567-3173

Svazek periodika

7

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

AU - Austrálie

Počet stran výsledku

15

Strana od-do

nestránkováno

Kód UT WoS článku

001454149700001

EID výsledku v databázi Scopus

2-s2.0-105001723825