Increased cardio-ankle vascular index in hyperlipidemic patients without diabetes or hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43110%2F15%3A43908560" target="_blank" >RIV/62156489:43110/15:43908560 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00061225 RIV/00216224:14110/15:00085181

Výsledek na webu

<a href="https://www.jstage.jst.go.jp/article/jat/22/3/22_24851/_pdf" target="_blank" >https://www.jstage.jst.go.jp/article/jat/22/3/22_24851/_pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5551/jat.24851" target="_blank" >10.5551/jat.24851</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased cardio-ankle vascular index in hyperlipidemic patients without diabetes or hypertension

Popis výsledku v původním jazyce

Aim: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. Methods: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera(R) 1500 system. Results: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00- 10.05) than in the controls (7.11, 95% CI 5.77-9.05; p&lt;0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p&lt;0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p&lt;0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p&lt;0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients (primary hypercholesterolemia, combined hyperlipidemia). Conclusions: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.

Název v anglickém jazyce

Increased cardio-ankle vascular index in hyperlipidemic patients without diabetes or hypertension

Popis výsledku anglicky

Aim: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. Methods: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera(R) 1500 system. Results: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00- 10.05) than in the controls (7.11, 95% CI 5.77-9.05; p&lt;0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p&lt;0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p&lt;0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p&lt;0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients (primary hypercholesterolemia, combined hyperlipidemia). Conclusions: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Atherosclerosis and Thrombosis

ISSN

1340-3478

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

12

Strana od-do

272-283

Kód UT WoS článku

000352271200008

EID výsledku v databázi Scopus

2-s2.0-84925354490