CZE studium interakcí některých kvarterních isochinolinových alkaloidů s DNA a DNA constituenty.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F05%3A00000799" target="_blank" >RIV/62156489:43210/05:00000799 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/05:00001999

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Capillary Zone Electrophoretic Studies of Interactions of Some Quaternary Isoquinoline Alkaloids with DNA Constituents and DNA

Popis výsledku v původním jazyce

Capillary zone electrophoresis was applied for the investigation of interactions of some quaternary isoquinoline alkaloids, namely sanguinarine, chelerythrine, berberine and jatrorrhizine, with DNA constituents and with DNA. None of these alkaloids attach covalently to nucleotides or to the whole DNA at physiological conditions. The interaction with DNA constituents is a non-covalent complexation based on weak intermolecular forces. Electrostatic attraction participates in the interaction but other types of intermolecular forces are involved as well. Cations were identified as the interacting forms of the alkaloids. The interaction with compounds derived from purine was always stronger that with those derived from pyrimidine. All alkaloids behaved analogously and similarly to ethidium bromide, the classic DNA intercalator.

Název v anglickém jazyce

Capillary Zone Electrophoretic Studies of Interactions of Some Quaternary Isoquinoline Alkaloids with DNA Constituents and DNA

Popis výsledku anglicky

Capillary zone electrophoresis was applied for the investigation of interactions of some quaternary isoquinoline alkaloids, namely sanguinarine, chelerythrine, berberine and jatrorrhizine, with DNA constituents and with DNA. None of these alkaloids attach covalently to nucleotides or to the whole DNA at physiological conditions. The interaction with DNA constituents is a non-covalent complexation based on weak intermolecular forces. Electrostatic attraction participates in the interaction but other types of intermolecular forces are involved as well. Cations were identified as the interacting forms of the alkaloids. The interaction with compounds derived from purine was always stronger that with those derived from pyrimidine. All alkaloids behaved analogously and similarly to ethidium bromide, the classic DNA intercalator.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrophoresis

ISSN

0173-0835

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

1673-1679

Kód UT WoS článku

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EID výsledku v databázi Scopus

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