Využití Brdičkovy reakce při analýze nízkomolekulárních thiolů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F08%3A00133943" target="_blank" >RIV/62156489:43210/08:00133943 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Utilizing of Brdicka reaction for analysis of low molecular mass thiols

Popis výsledku v původním jazyce

Low molecular mass thiols represents group of compounds rich in --SH moieties. Due to reactivity of this moiety thiols play number of crucial roles in organisms e.g. control of gene expression and receptor signalling, signal transduction and heavy metaldetoxification, and many others. Glutathione (GSH) belongs to the most important thiols. As a ubiquitous tripeptide thiol it is a vital intra- and extra-cellular protective antioxidant. Glutathione is found almost exclusively in its reduced form; since the enzyme, which reverts it from its oxidized form (GSSG) called glutathione reductase, is constitutively active and inducible upon oxidative stress. The sulfhydryl group of glutathione is highly reactive and is often found conjugated to other moleculessuch as nitric oxide (NO) via its sulfhydryl moiety. Particularly, nitrosation of the glutathione may serve as a signal event and/or as a deposition of NO to S nitrosoglutathione (GSNO). The aim of this work was to utilize Brdicka reactio

Název v anglickém jazyce

Utilizing of Brdicka reaction for analysis of low molecular mass thiols

Popis výsledku anglicky

Low molecular mass thiols represents group of compounds rich in --SH moieties. Due to reactivity of this moiety thiols play number of crucial roles in organisms e.g. control of gene expression and receptor signalling, signal transduction and heavy metaldetoxification, and many others. Glutathione (GSH) belongs to the most important thiols. As a ubiquitous tripeptide thiol it is a vital intra- and extra-cellular protective antioxidant. Glutathione is found almost exclusively in its reduced form; since the enzyme, which reverts it from its oxidized form (GSSG) called glutathione reductase, is constitutively active and inducible upon oxidative stress. The sulfhydryl group of glutathione is highly reactive and is often found conjugated to other moleculessuch as nitric oxide (NO) via its sulfhydryl moiety. Particularly, nitrosation of the glutathione may serve as a signal event and/or as a deposition of NO to S nitrosoglutathione (GSNO). The aim of this work was to utilize Brdicka reactio

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA522%2F07%2F0692" target="_blank" >GA522/07/0692: Studium tvorby thiolových sloučenin u rostlin - uplatnění při remediačních technologiích</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

12th International Conference on Electroanalysis

ISBN

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ISSN

0009-2770

e-ISSN

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Počet stran výsledku

2

Strana od-do

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Název nakladatele

Czech Chemical Society

Místo vydání

Prague, Czech Republic

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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