Stanovení metalothionenu u pacientů se spinocelulárním karcinomem hlavy a krku

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F08%3A00134122" target="_blank" >RIV/62156489:43210/08:00134122 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Metallothionein at patients with spinocellular carcinoma in head and neck area

Popis výsledku v původním jazyce

RESULTS: in the work was used electro-technology (Brdičková reaction) to determine the level of MT in the blood. We have primarily focused on the development and optimization of automated electrochemical detection. We've found that using Autosampler we are able to drive delivery of microliter sample and the results are very reproducible (bug fixing under 1%). The proposed instrumental measurement procedure was used to analyze blood samples of patients with squamous cell cancer. MT levels measured in patients with cancer were (2.30 +- 0.32) uM (n = 128). We observed that the level of MT in patients is four times higher than in a group of healthy volunteers (0.51 +- 0.20) uM (n = 58). Conclusion: In our work shows that the electrochemical method is a great advantage to be used for easy and quick determination of the level of thiolových compounds in biological samples. The results suggest that increased levels of MT is linked with cancer.

Název v anglickém jazyce

Metallothionein at patients with spinocellular carcinoma in head and neck area

Popis výsledku anglicky

RESULTS: in the work was used electro-technology (Brdičková reaction) to determine the level of MT in the blood. We have primarily focused on the development and optimization of automated electrochemical detection. We've found that using Autosampler we are able to drive delivery of microliter sample and the results are very reproducible (bug fixing under 1%). The proposed instrumental measurement procedure was used to analyze blood samples of patients with squamous cell cancer. MT levels measured in patients with cancer were (2.30 +- 0.32) uM (n = 128). We observed that the level of MT in patients is four times higher than in a group of healthy volunteers (0.51 +- 0.20) uM (n = 58). Conclusion: In our work shows that the electrochemical method is a great advantage to be used for easy and quick determination of the level of thiolových compounds in biological samples. The results suggest that increased levels of MT is linked with cancer.

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/IAA401990701" target="_blank" >IAA401990701: Studium vazby platinových cytostatik do struktury DNA; Vliv metalothioneinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

FONS, Sympozium klinicke biochemie

ISBN

978-80-903879-2-8

ISSN

—

e-ISSN

—

Počet stran výsledku

1

Strana od-do

—

Název nakladatele

STAPRO, Pardubice

Místo vydání

—

Místo konání akce

—

Datum konání akce

—

Typ akce podle státní příslušnosti

—

Kód UT WoS článku

—