Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00156084" target="_blank" >RIV/62156489:43210/10:00156084 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis

Popis výsledku v původním jazyce

Metallothionein (MT) is a ubiquitous cysteine-rich protein. One of the most known MT's functions is heavy metals detoxification and homeostating. Nowadays it is known, that MT is involved in regulation of gene expression, transcription, embryogenesis, immunomodulation and its antiapoptotic function was discovered recently. In cancer diseases, MT is associated with its diagnostics, course, prognosis and metastating. Enhanced MT expression leads to the formation of cytostatics resistance in tumour cells.Molecular mechanisms of these processes are still insufficiently known and understood. However it is known, that MT's function is closely related to its secondary and tertiary structure. Under physiological conditions, MT contains Zn(II) ions chelated incysteine clusters. Single MT molecules differ in zinc load and oxidation state. Recently it was found, that MT can form function aggregates in dependence on redox conditions and heavy metals concentration in the cell. These aggregates ar

Název v anglickém jazyce

Study of metallothionein aggregation in dependence on redox conditions and zinc concentration by using a chip capillary electrophoresis

Popis výsledku anglicky

Metallothionein (MT) is a ubiquitous cysteine-rich protein. One of the most known MT's functions is heavy metals detoxification and homeostating. Nowadays it is known, that MT is involved in regulation of gene expression, transcription, embryogenesis, immunomodulation and its antiapoptotic function was discovered recently. In cancer diseases, MT is associated with its diagnostics, course, prognosis and metastating. Enhanced MT expression leads to the formation of cytostatics resistance in tumour cells.Molecular mechanisms of these processes are still insufficiently known and understood. However it is known, that MT's function is closely related to its secondary and tertiary structure. Under physiological conditions, MT contains Zn(II) ions chelated incysteine clusters. Single MT molecules differ in zinc load and oxidation state. Recently it was found, that MT can form function aggregates in dependence on redox conditions and heavy metals concentration in the cell. These aggregates ar

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA401990701" target="_blank" >IAA401990701: Studium vazby platinových cytostatik do struktury DNA; Vliv metalothioneinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

25th International Symposium on MICROSCALE bIOsEPARATions MSN 2010

ISBN

978-80-254-6631-5

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

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Místo vydání

Praha

Místo konání akce

Praha, Česká republika

Datum konání akce

1. 1. 2010

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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