Biochemical profile of effect of deoxynivalenol supplemented by mouldy cereals on rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00166775" target="_blank" >RIV/62156489:43210/10:00166775 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Biochemical profile of effect of deoxynivalenol supplemented by mouldy cereals on rats

Popis výsledku v původním jazyce

The aims of this thesis consisted of investigating the impact mouldy grain contaminated with deoxynivalenol (DON) on the health status of rats and their ability to resist oxidative stress. Rats were 28 days feeding of diet supplemented with DON and others (organic and inorganic zinc, the addition of vitamins and mycosorb). Among the factors determining the levels of defences include peptides and proteins (glutathione, metallothionein (MT)). The highest concentration of MT was found in the tissues providing detoxification of xenobiotics, such as kidney (6.69 +/- 0.05 microg/ml) and liver (6.06 +/- 0.05 microg/ml). Half concentration was detected in heart, brain, testes and muscle (app. 3.0 microg/ml). In conclusion, the MT may play an important role inthe detoxification of mycotoxins. Its role is not fully understood, but this protein is most likely associated with the redistribution of ions important for transcription factors and its interaction with reactive oxygen species that can f

Název v anglickém jazyce

Biochemical profile of effect of deoxynivalenol supplemented by mouldy cereals on rats

Popis výsledku anglicky

The aims of this thesis consisted of investigating the impact mouldy grain contaminated with deoxynivalenol (DON) on the health status of rats and their ability to resist oxidative stress. Rats were 28 days feeding of diet supplemented with DON and others (organic and inorganic zinc, the addition of vitamins and mycosorb). Among the factors determining the levels of defences include peptides and proteins (glutathione, metallothionein (MT)). The highest concentration of MT was found in the tissues providing detoxification of xenobiotics, such as kidney (6.69 +/- 0.05 microg/ml) and liver (6.06 +/- 0.05 microg/ml). Half concentration was detected in heart, brain, testes and muscle (app. 3.0 microg/ml). In conclusion, the MT may play an important role inthe detoxification of mycotoxins. Its role is not fully understood, but this protein is most likely associated with the redistribution of ions important for transcription factors and its interaction with reactive oxygen species that can f

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP301%2F09%2FP436" target="_blank" >GP301/09/P436: Analýza metalothioneinu u karcinomu prostaty na úrovni DNA, RNA a proteinu.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2010 Proceedings of International Ph.D. Students Conference

ISBN

978-80-7375-453-2

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

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Název nakladatele

Mendelova univerzita v Brně, Agronomická fakulta

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2000

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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