Determination of metallothionein, glutathione and termostable protein fraction concentrations in tumour tissue from head and neck area

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00184598" target="_blank" >RIV/62156489:43210/10:00184598 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of metallothionein, glutathione and termostable protein fraction concentrations in tumour tissue from head and neck area

Popis výsledku v původním jazyce

Tumours of head and neck are one of the most incident tumour diseases. Well-timed diagnosis plays main role in their therapy. Aim of this work consisted in determination of metallothionein (MT), which could be new tumour marker. Determination of its concentration was carried out using electrochemical detection with use of differential pulse voltammetry. Concentrations of MT in samples of denaturized blood plasma of group of patients were about 2.3 uM with slight differences in accordance with localization of tumours. Contents of glutathione and total proteins in denaturized were determined chromatographically and by the help of Biuret reaction. Rate of concentrations levels of GSH/GSSG was varying from 1.31 to 17.66.

Název v anglickém jazyce

Determination of metallothionein, glutathione and termostable protein fraction concentrations in tumour tissue from head and neck area

Popis výsledku anglicky

Tumours of head and neck are one of the most incident tumour diseases. Well-timed diagnosis plays main role in their therapy. Aim of this work consisted in determination of metallothionein (MT), which could be new tumour marker. Determination of its concentration was carried out using electrochemical detection with use of differential pulse voltammetry. Concentrations of MT in samples of denaturized blood plasma of group of patients were about 2.3 uM with slight differences in accordance with localization of tumours. Contents of glutathione and total proteins in denaturized were determined chromatographically and by the help of Biuret reaction. Rate of concentrations levels of GSH/GSSG was varying from 1.31 to 17.66.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biochemical Technology

ISSN

0974-2328

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

2

Strana od-do

29-30

Kód UT WoS článku

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EID výsledku v databázi Scopus

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