Determination of sarcosine as possible tumour marker of prostate tumours

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F10%3A00184603" target="_blank" >RIV/62156489:43210/10:00184603 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of sarcosine as possible tumour marker of prostate tumours

Popis výsledku v původním jazyce

Amino acid sarcosine, known also as N-methylglycine, may be established as new very important marker in prostate malignant tumours and may be determined by very simple test. Cancer of prostate is one of the most incident types of malignant tumours in men. More than one thousand men in Czech Republic die due to this disease. As well as in the case of other malignant tumours, for initiation of treatment well timed diagnosis of disease is necessary. For determination of sarcosine we employed the ionex chromatography with postcolumn derivatization by ninhydrin. We achieved the calibration curve linearity R2=0.9984 with limit of detection 500nM. Moreover we confirmed that the calibration was not affected by presence of another aminoacids and ensure that selectivity of separation is near to 99% efficiency.

Název v anglickém jazyce

Determination of sarcosine as possible tumour marker of prostate tumours

Popis výsledku anglicky

Amino acid sarcosine, known also as N-methylglycine, may be established as new very important marker in prostate malignant tumours and may be determined by very simple test. Cancer of prostate is one of the most incident types of malignant tumours in men. More than one thousand men in Czech Republic die due to this disease. As well as in the case of other malignant tumours, for initiation of treatment well timed diagnosis of disease is necessary. For determination of sarcosine we employed the ionex chromatography with postcolumn derivatization by ninhydrin. We achieved the calibration curve linearity R2=0.9984 with limit of detection 500nM. Moreover we confirmed that the calibration was not affected by presence of another aminoacids and ensure that selectivity of separation is near to 99% efficiency.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biochemical Technology

ISSN

0974-2328

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

2

Strana od-do

7-8

Kód UT WoS článku

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EID výsledku v databázi Scopus

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