Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarke

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F11%3A00173489" target="_blank" >RIV/62156489:43210/11:00173489 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/elps.201000519" target="_blank" >http://dx.doi.org/10.1002/elps.201000519</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201000519" target="_blank" >10.1002/elps.201000519</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarke

Popis výsledku v původním jazyce

Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosedcases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 -- 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false p

Název v anglickém jazyce

Electrophoretic fingerprint metallothionein analysis as a potential prostate cancer biomarke

Popis výsledku anglicky

Prostate-specific antigen (PSA) is a routinely used marker of prostate cancer; however, the cut-off values for unambiguous positive/negative prostate cancer diagnoses are not defined. Therefore, despite the best effort, certain percentage of misdiagnosedcases is being recorded every year. For this reason, search formore specific diagnosticmarkers is of great interest. In this study, systematic comparison of PSA and metallothionein (MT) levels in blood serum of 46 prostate cancer-diagnosed patients is presented. It is clearly demonstrated that PSA levels vary significantly and despite normal total PSA values in the range of 0 -- 4 ng/mL were obtained in over 36.9% of cases, positive prostate cancer was diagnosed by biopsy. In contrary, MT levels were considerably elevated in all tested samples and no significant variations were observed. These results are indicating the potential of MT as an additional prostate cancer marker reducing, in combination with PSA, the probability of false p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/KAN208130801" target="_blank" >KAN208130801: Nové konstrukce a využití nanobiosenzorů a nanosenzorů v medicíně (NANOSEMED)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1952-1961

Kód UT WoS článku

294179800005

EID výsledku v databázi Scopus

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