Nanoparticles-based carriers for gene therapy and drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F13%3A00213992" target="_blank" >RIV/62156489:43210/13:00213992 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/9781118636299.ch16/summary" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/9781118636299.ch16/summary</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9781118636299.ch16" target="_blank" >10.1002/9781118636299.ch16</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanoparticles-based carriers for gene therapy and drug delivery

Popis výsledku v původním jazyce

This review provides a brief overview of the variety of carriers employed for targeted delivery used in gene and cancer therapy summarizing advantages and disadvantages of each approach. Particularly, we aim our attention at magnetic particles and particles made from other materials with various surface modification (oligonucleotides, DNA, RNA, siRNA, miRNA, polyethylene glycol, poly(lactic-co-glycolic acid)). Moreover, we pay attention to magnetofection as one of the promising approach for gene therapy. Further, we briefly focus on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, cisplatin, curcumin, fluorouracil and geldanamycin), antiviral/bacterial agents (peptides, antibiotics, antivirotics) and/or nucleic acids encapsulate in delivery nanotechnology system. The influence of their combination with aforementioned nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility is discussed.

Název v anglickém jazyce

Nanoparticles-based carriers for gene therapy and drug delivery

Popis výsledku anglicky

This review provides a brief overview of the variety of carriers employed for targeted delivery used in gene and cancer therapy summarizing advantages and disadvantages of each approach. Particularly, we aim our attention at magnetic particles and particles made from other materials with various surface modification (oligonucleotides, DNA, RNA, siRNA, miRNA, polyethylene glycol, poly(lactic-co-glycolic acid)). Moreover, we pay attention to magnetofection as one of the promising approach for gene therapy. Further, we briefly focus on several anticancer agents (paclitaxel, docetaxel, camptothecin, doxorubicin, cisplatin, curcumin, fluorouracil and geldanamycin), antiviral/bacterial agents (peptides, antibiotics, antivirotics) and/or nucleic acids encapsulate in delivery nanotechnology system. The influence of their combination with aforementioned nanoparticulate transporters to their properties such as cytotoxicity, short life time and/or solubility is discussed.

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

—

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanomedicine for drug delivery and therapeutics

ISBN

978-1-118-41409-5

Počet stran výsledku

23

Strana od-do

471-493

Počet stran knihy

449

Název nakladatele

Wiley, Scrivener Publishing

Místo vydání

New York

Kód UT WoS kapitoly

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