Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F14%3A00225111" target="_blank" >RIV/62156489:43210/14:00225111 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/14:43872966 RIV/00216305:26620/14:PU109895

Výsledek na webu

<a href="http://dx.doi.org/10.1002/elps.201300393" target="_blank" >http://dx.doi.org/10.1002/elps.201300393</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201300393" target="_blank" >10.1002/elps.201300393</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging

Popis výsledku v původním jazyce

Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60)surface was oxidized by concentrated nitric acid, which enabled simple DOX--fullerene conjugation based on pi-pi stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cel

Název v anglickém jazyce

Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging

Popis výsledku anglicky

Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60)surface was oxidized by concentrated nitric acid, which enabled simple DOX--fullerene conjugation based on pi-pi stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cel

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

O - Projekt operacniho programu

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Svazek periodika

35

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1040-1049

Kód UT WoS článku

333644600016

EID výsledku v databázi Scopus

—