Characterization of Multi-Walled Carbon Nanotubes Double-Functionalization with Cytostatic Drug Etoposide and Phosphorothioate Oligodeoxynucleotides
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907682" target="_blank" >RIV/62156489:43210/15:43907682 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/15:10306887 RIV/00216305:26620/15:PU118482 RIV/00064203:_____/15:10306887
Výsledek na webu
<a href="http://www.electrochemsci.org/papers/vol10/100907707.pdf" target="_blank" >http://www.electrochemsci.org/papers/vol10/100907707.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Characterization of Multi-Walled Carbon Nanotubes Double-Functionalization with Cytostatic Drug Etoposide and Phosphorothioate Oligodeoxynucleotides
Popis výsledku v původním jazyce
Carbon nanomaterials possess unique structural and physicochemical properties, and thus they are broadly utilized as carriers for a variety of therapeutic agents in nanomedicinal applications. Herein we present an electrochemical characterization of binding capability of acidic oxidized multi-walled carbon nanotubes (oMWCNTs) modified with poly(ethylene glycol) towards common cytostatic drug etoposide (or VP-16). The comparison of willingness of oMWCNTs and MWCNTs-PEG to form complexes with etoposide revealed significantly higher capacity in PEGylated variant of carbon nanotubes (the 15 mM etoposide loading capacity was approximately 46.4% in 2 mg of MWCNT-PEG or 28.1% in equal amount of oMWCNT). To obtain a multifunctional nanotransporter we employedthe phosphorothioate oligodeoxynucleotide (PODN), which could further extend the possible biological effects of MWCNT-PEG-Etoposide complex. By using square wave voltammetry, the binding capacity of 2 mg of MWCNT-PEG-Etoposide (15 mM) tow
Název v anglickém jazyce
Characterization of Multi-Walled Carbon Nanotubes Double-Functionalization with Cytostatic Drug Etoposide and Phosphorothioate Oligodeoxynucleotides
Popis výsledku anglicky
Carbon nanomaterials possess unique structural and physicochemical properties, and thus they are broadly utilized as carriers for a variety of therapeutic agents in nanomedicinal applications. Herein we present an electrochemical characterization of binding capability of acidic oxidized multi-walled carbon nanotubes (oMWCNTs) modified with poly(ethylene glycol) towards common cytostatic drug etoposide (or VP-16). The comparison of willingness of oMWCNTs and MWCNTs-PEG to form complexes with etoposide revealed significantly higher capacity in PEGylated variant of carbon nanotubes (the 15 mM etoposide loading capacity was approximately 46.4% in 2 mg of MWCNT-PEG or 28.1% in equal amount of oMWCNT). To obtain a multifunctional nanotransporter we employedthe phosphorothioate oligodeoxynucleotide (PODN), which could further extend the possible biological effects of MWCNT-PEG-Etoposide complex. By using square wave voltammetry, the binding capacity of 2 mg of MWCNT-PEG-Etoposide (15 mM) tow
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CG - Elektrochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Electrochemical Science
ISSN
1452-3981
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
CS - Srbsko a Černá Hora
Počet stran výsledku
13
Strana od-do
7707-7719
Kód UT WoS článku
000365101700069
EID výsledku v databázi Scopus
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