Hemagglutinin structure, membrane fusion and virus entry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F15%3A43907751" target="_blank" >RIV/62156489:43210/15:43907751 - isvavai.cz</a>

Výsledek na webu

<a href="http://web2.mendelu.cz/af_239_nanotech/J_Met_Nano/0115/pdf/JMN1-2015-9.pdf" target="_blank" >http://web2.mendelu.cz/af_239_nanotech/J_Met_Nano/0115/pdf/JMN1-2015-9.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hemagglutinin structure, membrane fusion and virus entry

Popis výsledku v původním jazyce

Hemagglutinin (HA) is an antigenic glycoprotein, which is placed on the surface of the influenza viruses. It is responsible for binding the virus to the host cell, that is being infected. The name ""hemagglutinin"" comes from the ability of protein to cause erythrocytes to agglutinate (""clump together""). The process is like this: Hemagglutinin (HA) binds to the monosaccharide sialic acid which is present on the surface of its target host cells. The cell membrane then engulfs the virus through endocytosis and followed by formation of endosome. The cell then attempts to begin digesting the contents of the endosome by acidifying its interior and transforming it into a lysosome. When the pH decrease to 6.0, the HA molecule becomes partially unfold, and release a hydrophobic portion of peptide chain that was previously hidden. This so-called ""fusion peptide"" acts like a molecular grapple hook for lock on the endosomal membrane. The rest of the HA molecule refolds into a new structure an

Název v anglickém jazyce

Hemagglutinin structure, membrane fusion and virus entry

Popis výsledku anglicky

Hemagglutinin (HA) is an antigenic glycoprotein, which is placed on the surface of the influenza viruses. It is responsible for binding the virus to the host cell, that is being infected. The name ""hemagglutinin"" comes from the ability of protein to cause erythrocytes to agglutinate (""clump together""). The process is like this: Hemagglutinin (HA) binds to the monosaccharide sialic acid which is present on the surface of its target host cells. The cell membrane then engulfs the virus through endocytosis and followed by formation of endosome. The cell then attempts to begin digesting the contents of the endosome by acidifying its interior and transforming it into a lysosome. When the pH decrease to 6.0, the HA molecule becomes partially unfold, and release a hydrophobic portion of peptide chain that was previously hidden. This so-called ""fusion peptide"" acts like a molecular grapple hook for lock on the endosomal membrane. The rest of the HA molecule refolds into a new structure an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Metallomics and Nanotechnologies

ISSN

2336-3940

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

53-56

Kód UT WoS článku

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EID výsledku v databázi Scopus

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