Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43911834" target="_blank" >RIV/62156489:43210/17:43911834 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00094919 RIV/00216305:26620/17:PU124805

Výsledek na webu

<a href="https://doi.org/10.1002/jbt.21891" target="_blank" >https://doi.org/10.1002/jbt.21891</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbt.21891" target="_blank" >10.1002/jbt.21891</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Popis výsledku v původním jazyce

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione)were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereasMTand glutathione were decreased. GenotypeAAof rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameterswere not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Název v anglickém jazyce

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Popis výsledku anglicky

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione)were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereasMTand glutathione were decreased. GenotypeAAof rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameterswere not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biochemical and Molecular Toxicology

ISSN

1095-6670

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

&quot;nestrankovano&quot;

Kód UT WoS článku

000403147800009

EID výsledku v databázi Scopus

2-s2.0-85008474273