The effect of selenium nanoparticles on the antioxidant potential of laboratory rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F17%3A43912538" target="_blank" >RIV/62156489:43210/17:43912538 - isvavai.cz</a>

Výsledek na webu

<a href="https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of selenium nanoparticles on the antioxidant potential of laboratory rats

Popis výsledku v původním jazyce

The aim of the experiment was to determine the influence of different forms of selenium (sodium selenite, selenium nanoparticles) on the antioxidant status of laboratory rats. The male of Wistar albino rats strain were sorted into 4 groups. The first group (n = 5) served as control with no selenium (Se) administration. The second group was fed with mixture containing 1.2 mg/kg/diet of sodium selenite (Na2SeO3). The third (n = 5) and the fourth group (n = 5) were fed with different forms of selenium nanoparticles containing 1.2 mg Se/kg/diet. Selenium nanoparticles were modified by poly(vinylalcohol) (PVA 49 kDa, PVA 100 kDa). After 30 days of experiment, the rats were slaughtered and the total content of selenium in liver and blood tissue and also changes in concentration of reduced (GSH) and oxidized (GSSG) form of glutathione were measured. In liver samples, a statistically significant increase in the amount of selenium was found only in the Na2SeO3 group (by 59%), although the increase occurred in all of the experimental groups. In the blood, the amount of selenium increased for Na2SeO3 and Se-100. These results were statistically significant. GSH and GSSG were statistically significant only in blood samples where GSH was decreased in all the experimental groups (Na2SeO3 by 60%, Se-49 by 56%, Se-100 by 83%) and increased only in the Na2SeO3 group (by 96%).

Název v anglickém jazyce

The effect of selenium nanoparticles on the antioxidant potential of laboratory rats

Popis výsledku anglicky

The aim of the experiment was to determine the influence of different forms of selenium (sodium selenite, selenium nanoparticles) on the antioxidant status of laboratory rats. The male of Wistar albino rats strain were sorted into 4 groups. The first group (n = 5) served as control with no selenium (Se) administration. The second group was fed with mixture containing 1.2 mg/kg/diet of sodium selenite (Na2SeO3). The third (n = 5) and the fourth group (n = 5) were fed with different forms of selenium nanoparticles containing 1.2 mg Se/kg/diet. Selenium nanoparticles were modified by poly(vinylalcohol) (PVA 49 kDa, PVA 100 kDa). After 30 days of experiment, the rats were slaughtered and the total content of selenium in liver and blood tissue and also changes in concentration of reduced (GSH) and oxidized (GSSG) form of glutathione were measured. In liver samples, a statistically significant increase in the amount of selenium was found only in the Na2SeO3 group (by 59%), although the increase occurred in all of the experimental groups. In the blood, the amount of selenium increased for Na2SeO3 and Se-100. These results were statistically significant. GSH and GSSG were statistically significant only in blood samples where GSH was decreased in all the experimental groups (Na2SeO3 by 60%, Se-49 by 56%, Se-100 by 83%) and increased only in the Na2SeO3 group (by 96%).

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

MendelNet 2017: Proceedings of International PhD Students Conference

ISBN

978-80-7509-529-9

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

5

Strana od-do

285-289

Název nakladatele

Mendelova univerzita v Brně

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

8. 11. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000440194500051