Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43913431" target="_blank" >RIV/62156489:43210/18:43913431 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00102914 RIV/62157124:16170/18:43877270 RIV/62157124:16810/18:43877270 RIV/00216305:26620/18:PU127725 RIV/65269705:_____/18:00068566

Výsledek na webu

<a href="http://dx.doi.org/10.1038/s41598-018-23072-4" target="_blank" >http://dx.doi.org/10.1038/s41598-018-23072-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-018-23072-4" target="_blank" >10.1038/s41598-018-23072-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Popis výsledku v původním jazyce

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog&apos;s olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Název v anglickém jazyce

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Popis výsledku anglicky

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog&apos;s olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

21 March

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

"Nestrankovano"

Kód UT WoS článku

000427926500002

EID výsledku v databázi Scopus

2-s2.0-85044303199