Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43913709" target="_blank" >RIV/62156489:43210/18:43913709 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43410/18:43913709 RIV/00216305:26620/18:PU128162

Výsledek na webu

<a href="https://doi.org/10.1007/s11696-018-0400-3" target="_blank" >https://doi.org/10.1007/s11696-018-0400-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11696-018-0400-3" target="_blank" >10.1007/s11696-018-0400-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

Popis výsledku v původním jazyce

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 A mu M were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.

Název v anglickém jazyce

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

Popis výsledku anglicky

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 A mu M were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

—

Svazek periodika

72

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

1437-1449

Kód UT WoS článku

000433202900012

EID výsledku v databázi Scopus

2-s2.0-85047625393