Prevalence of cervical human papillomavirus is associated with p16 expression and irregular menstrual cycles among married Jordanian women
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F18%3A43914310" target="_blank" >RIV/62156489:43210/18:43914310 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.12892/ejgo4318.2018" target="_blank" >http://dx.doi.org/10.12892/ejgo4318.2018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.12892/ejgo4318.2018" target="_blank" >10.12892/ejgo4318.2018</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Prevalence of cervical human papillomavirus is associated with p16 expression and irregular menstrual cycles among married Jordanian women
Popis výsledku v původním jazyce
Persistent infection with high-risk human papillomavirus (HPV) is the leading cause of cervical cancer worldwide. In this study, we used immunohistochemical methods to investigate the prevalence of HPV among Jordanian women who visited local gynaecological clinics. Expression of HPV and p16 protein was analysed to assess the high-risk prevalence of the virus. Accordingly, HPV was positively expressed in 41% (57 out of 140) of the cases and expression of p16 was found in 28% (39 out of 140) of the cases. Factor analysis showed that irregular cycles increased the chances of HPV by 13.342-fold (p = 0.001) and p16 expression by 17.091-fold (p < 0.001). Age-adjusted odds ratios were 12.923-fold for HPV (p = 0.002) and 16.986-fold for p16 expression (p < 0.001). In conclusion, awareness, screening, and vaccination are key preventive measures in the fight against HPV and cervical cancer are important in conservative countries such as Jordan.
Název v anglickém jazyce
Prevalence of cervical human papillomavirus is associated with p16 expression and irregular menstrual cycles among married Jordanian women
Popis výsledku anglicky
Persistent infection with high-risk human papillomavirus (HPV) is the leading cause of cervical cancer worldwide. In this study, we used immunohistochemical methods to investigate the prevalence of HPV among Jordanian women who visited local gynaecological clinics. Expression of HPV and p16 protein was analysed to assess the high-risk prevalence of the virus. Accordingly, HPV was positively expressed in 41% (57 out of 140) of the cases and expression of p16 was found in 28% (39 out of 140) of the cases. Factor analysis showed that irregular cycles increased the chances of HPV by 13.342-fold (p = 0.001) and p16 expression by 17.091-fold (p < 0.001). Age-adjusted odds ratios were 12.923-fold for HPV (p = 0.002) and 16.986-fold for p16 expression (p < 0.001). In conclusion, awareness, screening, and vaccination are key preventive measures in the fight against HPV and cervical cancer are important in conservative countries such as Jordan.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30204 - Oncology
Návaznosti výsledku
Projekt
<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
European Journal of Gynaecological Oncology
ISSN
0392-2936
e-ISSN
—
Svazek periodika
39
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
CA - Kanada
Počet stran výsledku
7
Strana od-do
779-785
Kód UT WoS článku
000444420100017
EID výsledku v databázi Scopus
2-s2.0-85053315104