High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43914979" target="_blank" >RIV/62156489:43210/19:43914979 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/19:PU131625

Výsledek na webu

<a href="https://doi.org/10.1016/j.aca.2018.09.006" target="_blank" >https://doi.org/10.1016/j.aca.2018.09.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aca.2018.09.006" target="_blank" >10.1016/j.aca.2018.09.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Popis výsledku v původním jazyce

The deposition of chemical reagent inks on paper is a crucial step in the development and fabrication of microfluidic paper-based analytical devices (mu PADs). A pen-plotting approach, delivering chemical ink deposition using technical pens filled with reagents and inserted into a desktop electronic plotter, is shown herein to be a versatile, low-cost, simple, rapid, reproducible, and high-throughput solution. The volume of the deposited ink was quantified gravimetrically, confirming that nanoliter volumes of reagents can be deposited reproducibly (e.g. 7.55 +/- 0.37 nL/mm for a plotting speed of 10 cm/s) in detection zones of mu PADs, typically spatially defined using wax printing. This approach was further investigated with regard to deposition of reagents in different geometrical forms (circular and linear), so demonstrating its applicability for preparation of mu PADs with flexible design and application. By adjusting the plotting speed for linear deposition, lines with a relatively large range of widths (approximate to 628-1192 mm) were created. Circular deposition was also demonstrated via delivery of reagents within wax printed circular fluidic barriers of a range of diameters (inner diameter = 1.5-7 mm). These capabilities were practically demonstrated via the fabrication of mu PADs, based upon differing detection principles for determination of aluminum in natural waters using Morin as the fluorescent reagent. Traditional mu PADs based on digital image colorimetry (DIC) were produced using circular deposition, whilst distance-based mu PADs exploited linear deposition. Both types of mu PADs developed using this method showed excellent precision for determination of trace concentrations of aluminium (average RSDs = 3.38% and 6.45%, and LODs = 0.5 ng (0.25 ppm) and 2 ng (0.5 ppm), for traditional and distance-based detection, respectively).

Název v anglickém jazyce

High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Popis výsledku anglicky

The deposition of chemical reagent inks on paper is a crucial step in the development and fabrication of microfluidic paper-based analytical devices (mu PADs). A pen-plotting approach, delivering chemical ink deposition using technical pens filled with reagents and inserted into a desktop electronic plotter, is shown herein to be a versatile, low-cost, simple, rapid, reproducible, and high-throughput solution. The volume of the deposited ink was quantified gravimetrically, confirming that nanoliter volumes of reagents can be deposited reproducibly (e.g. 7.55 +/- 0.37 nL/mm for a plotting speed of 10 cm/s) in detection zones of mu PADs, typically spatially defined using wax printing. This approach was further investigated with regard to deposition of reagents in different geometrical forms (circular and linear), so demonstrating its applicability for preparation of mu PADs with flexible design and application. By adjusting the plotting speed for linear deposition, lines with a relatively large range of widths (approximate to 628-1192 mm) were created. Circular deposition was also demonstrated via delivery of reagents within wax printed circular fluidic barriers of a range of diameters (inner diameter = 1.5-7 mm). These capabilities were practically demonstrated via the fabrication of mu PADs, based upon differing detection principles for determination of aluminum in natural waters using Morin as the fluorescent reagent. Traditional mu PADs based on digital image colorimetry (DIC) were produced using circular deposition, whilst distance-based mu PADs exploited linear deposition. Both types of mu PADs developed using this method showed excellent precision for determination of trace concentrations of aluminium (average RSDs = 3.38% and 6.45%, and LODs = 0.5 ng (0.25 ppm) and 2 ng (0.5 ppm), for traditional and distance-based detection, respectively).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytica Chimica Acta

ISSN

0003-2670

e-ISSN

—

Svazek periodika

1047

Číslo periodika v rámci svazku

24 January

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

115-123

Kód UT WoS článku

000453384400013

EID výsledku v databázi Scopus

2-s2.0-85054713769