Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43915184" target="_blank" >RIV/62156489:43210/19:43915184 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/19:10394605 RIV/00216208:11130/19:10394605 RIV/00216305:26620/19:PU132589 RIV/00064203:_____/19:10394605

Výsledek na webu

<a href="https://doi.org/10.1016/j.bbcan.2019.01.001" target="_blank" >https://doi.org/10.1016/j.bbcan.2019.01.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbcan.2019.01.001" target="_blank" >10.1016/j.bbcan.2019.01.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine

Popis výsledku v původním jazyce

So far multiple differences in prostate cancer-specific amino acids metabolism have been discovered. Moreover, attempts to utilize these alterations for prostate cancer diagnosis and treatment have been made. The prostate cancer metabolism and biosynthesis of amino acids are particularly focused on anaplerosis more than on energy production. Other crucial requirements on amino acids pool come from the serine, one-carbon cycle, glycine synthesis pathway and folate metabolism forming major sources of interproducts for synthesis of nucleobases necessary for rapidly proliferating cells. Considering the lack of some amino acids biosynthetic pathways and/or their extraordinary importance for prostate cancer cells, there is a widespread potential for targeted therapeutic applications with no effect on non-malignant cells. This review summarizes the up-to-date knowledge of the importance of amino acids for prostate cancer pathogenesis with a special emphasis on potential applications of metabolic variabilities in the new oncologic paradigm of precision medicine.

Název v anglickém jazyce

Prostate cancer-specific hallmarks of amino acids metabolism: Towards a paradigm of precision medicine

Popis výsledku anglicky

So far multiple differences in prostate cancer-specific amino acids metabolism have been discovered. Moreover, attempts to utilize these alterations for prostate cancer diagnosis and treatment have been made. The prostate cancer metabolism and biosynthesis of amino acids are particularly focused on anaplerosis more than on energy production. Other crucial requirements on amino acids pool come from the serine, one-carbon cycle, glycine synthesis pathway and folate metabolism forming major sources of interproducts for synthesis of nucleobases necessary for rapidly proliferating cells. Considering the lack of some amino acids biosynthetic pathways and/or their extraordinary importance for prostate cancer cells, there is a widespread potential for targeted therapeutic applications with no effect on non-malignant cells. This review summarizes the up-to-date knowledge of the importance of amino acids for prostate cancer pathogenesis with a special emphasis on potential applications of metabolic variabilities in the new oncologic paradigm of precision medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

ISSN

0304-419X

e-ISSN

—

Svazek periodika

1871

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

248-258

Kód UT WoS článku

000469889900004

EID výsledku v databázi Scopus

2-s2.0-85060969670