Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43917973" target="_blank" >RIV/62156489:43210/20:43917973 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/20:PU136649

Výsledek na webu

<a href="https://doi.org/10.37904/nanocon.2019.8611" target="_blank" >https://doi.org/10.37904/nanocon.2019.8611</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2019.8611" target="_blank" >10.37904/nanocon.2019.8611</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

Popis výsledku v původním jazyce

Cancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.

Název v anglickém jazyce

Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

Popis výsledku anglicky

Cancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2019: Conference Proceedings

ISBN

978-80-87294-95-6

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

4

Strana od-do

402-405

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

16. 10. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000664115400067