Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F21%3A43920256" target="_blank" >RIV/62156489:43210/21:43920256 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3390/ijms221810043" target="_blank" >https://doi.org/10.3390/ijms221810043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms221810043" target="_blank" >10.3390/ijms221810043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

Popis výsledku v původním jazyce

Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, &quot;bits and pieces&quot; of its complex etiopathology stillremain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.

Název v anglickém jazyce

Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction

Popis výsledku anglicky

Inflammation is among the core causatives of male infertility. Despite male infertility being a serious global issue, &quot;bits and pieces&quot; of its complex etiopathology stillremain missing. During inflammation, levels of proinflammatory mediators in the male reproductive tract are greater than usual. According to epidemiological research, in numerous cases of male infertility, patients suffer from acute or chronic inflammation of the genitourinary tract which typically occurs without symptoms. Inflammatory responses in the male genital system are inextricably linked to oxidative stress (OS). OS is detrimental to male fertility parameters as it causes oxidative damage to reproductive cells and intracellular components. Multifarious male infertility causative factors pave the way for impairing male reproductive functions via the common mechanisms of OS and inflammation, both of which are interlinked pathophysiological processes, and the occurrence of any one of them induces the other. Both processes may be simultaneously found in the pathogenesis of male infertility. Thus, the present article aims to explain the role of inflammation and OS in male infertility in detail, as well as to show the mechanistic pathways that link causative factors of male reproductive tract inflammation, OS induction, and oxidant-sensitive cellular cascades leading to male infertility.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

20

Strana od-do

10043

Kód UT WoS článku

000699720700001

EID výsledku v databázi Scopus

2-s2.0-85115105953