Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43921786" target="_blank" >RIV/62156489:43210/22:43921786 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/22:A2402FQJ

Výsledek na webu

<a href="https://doi.org/10.21101/cejph.a6810" target="_blank" >https://doi.org/10.21101/cejph.a6810</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21101/cejph.a6810" target="_blank" >10.21101/cejph.a6810</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview

Popis výsledku v původním jazyce

Celiac disease (CD) is a disorder that affects both children and adults. Over the few last decades, several new atypical cases have been identified through improved diagnostic tools. On the other hand, the onset of CD at a later age, including atypical CD forms whose clinical picture overlaps with other autoimmune diseases, shows that currently there are several unknown gene mutations, which could be responsible for the disease development. Non-celiac gluten sensitivity (NCGS) is entity included by the ingestion of gluten leading to intestinal, or extraintestinal symptoms that improve once the gluten is removed from the nutrition. In this article relationships between genetically modified rodent animals with previously unknown multiple organ changes and CD, respectively NCGS are reviewed. Relationships between the small bowel histological changes and other organs pathology are discussed. Results of research document that changes have similar genetic background and can develop to serious autoimmune systematic diseases, including small bowel inflammation resembling atypical CD or NCGS. These may have extra-intestinal symptomatology but without a clear explanation of causes and differences in their manifestations. Research on animal models helps to discover links between several disorders associated with gastrointestinal damage. New methods based on individual gene mutations can help in atypical adult CD and NCGS recognitions in the future.

Název v anglickém jazyce

Genetically modified rodent models and celiac, non-celiac gluten sensitivity: a minireview

Popis výsledku anglicky

Celiac disease (CD) is a disorder that affects both children and adults. Over the few last decades, several new atypical cases have been identified through improved diagnostic tools. On the other hand, the onset of CD at a later age, including atypical CD forms whose clinical picture overlaps with other autoimmune diseases, shows that currently there are several unknown gene mutations, which could be responsible for the disease development. Non-celiac gluten sensitivity (NCGS) is entity included by the ingestion of gluten leading to intestinal, or extraintestinal symptoms that improve once the gluten is removed from the nutrition. In this article relationships between genetically modified rodent animals with previously unknown multiple organ changes and CD, respectively NCGS are reviewed. Relationships between the small bowel histological changes and other organs pathology are discussed. Results of research document that changes have similar genetic background and can develop to serious autoimmune systematic diseases, including small bowel inflammation resembling atypical CD or NCGS. These may have extra-intestinal symptomatology but without a clear explanation of causes and differences in their manifestations. Research on animal models helps to discover links between several disorders associated with gastrointestinal damage. New methods based on individual gene mutations can help in atypical adult CD and NCGS recognitions in the future.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Public Health

ISSN

1210-7778

e-ISSN

1803-1048

Svazek periodika

30

Číslo periodika v rámci svazku

Supplement

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

"S27"-"S31"

Kód UT WoS článku

000951157900006

EID výsledku v databázi Scopus

2-s2.0-85134623279