Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F17%3A43910984" target="_blank" >RIV/62156489:43410/17:43910984 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.2147/IJN.S124318" target="_blank" >https://doi.org/10.2147/IJN.S124318</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJN.S124318" target="_blank" >10.2147/IJN.S124318</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Popis výsledku v původním jazyce

Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%+-1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%+-2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%+-2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

Název v anglickém jazyce

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Popis výsledku anglicky

Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%+-1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%+-2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%+-2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Nanomedicine

ISSN

1176-9114

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

14 March

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

11

Strana od-do

2021-2031

Kód UT WoS článku

000396151900001

EID výsledku v databázi Scopus

2-s2.0-85015865201