Unlocking nature’s pharmacy: diversity of medicinal properties and mycochemicals in the family Hymenochaetaceae (Agaricomycetes, Basidiomycota)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F24%3A43926095" target="_blank" >RIV/62156489:43410/24:43926095 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.5943/mycosphere/15/1/27" target="_blank" >https://doi.org/10.5943/mycosphere/15/1/27</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5943/mycosphere/15/1/27" target="_blank" >10.5943/mycosphere/15/1/27</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Unlocking nature’s pharmacy: diversity of medicinal properties and mycochemicals in the family Hymenochaetaceae (Agaricomycetes, Basidiomycota)

Popis výsledku v původním jazyce

Hymenochaetaceae is a large and noteworthy family of macrobasidiomycetes predominantly growing on woody plants. Several Hymenochaetaceae members have a long history of recognition in traditional medicine and modern pharmacological studies have demonstrated their therapeutic properties. This review comprehensively surveys the studies on biological activities and mycochemical compounds reported from the Hymenochaetaceae species so far. There are 124 potential species from 27 genera in Hymenochaetaceae with at least one bioactive metabolite and/or biological property. A diverse range of metabolites were found (ca. 500 compounds) classified mainly into terpenoids, styrylpyrones, steroids, phenolics, polysaccharides, and other compounds. Numerous novel sesquiterpenoids, triterpenoids, steroids, and styrylpyrones have been isolated from the family. Medicinal properties cover a range of about 100 types of bioactivities, more predominantly antioxidant, antitumor, antidiabetic, immunomodulatory, anti-inflammatory, antibacterial, and antifungal effects. The role of Hymenochaetaceae members in aesthetic medicine is also discussed. Molecular phylogenetic reconstructions reveal that the medicinal species are distributed in 27 monophyletic clades, and 20 medicinal species are types of their respective genera (generic types). So far most of medicinal Hymenochaetaceae species are shown to be distributed in Asia, particularly in China. Considering the drawbacks imposed by improper characterization of Hymenochaetaceae isolates in biomedical studies, general recommendations are given with the aim of encouraging greater focus on accurately identifying the medicinal fungal species.

Název v anglickém jazyce

Unlocking nature’s pharmacy: diversity of medicinal properties and mycochemicals in the family Hymenochaetaceae (Agaricomycetes, Basidiomycota)

Popis výsledku anglicky

Hymenochaetaceae is a large and noteworthy family of macrobasidiomycetes predominantly growing on woody plants. Several Hymenochaetaceae members have a long history of recognition in traditional medicine and modern pharmacological studies have demonstrated their therapeutic properties. This review comprehensively surveys the studies on biological activities and mycochemical compounds reported from the Hymenochaetaceae species so far. There are 124 potential species from 27 genera in Hymenochaetaceae with at least one bioactive metabolite and/or biological property. A diverse range of metabolites were found (ca. 500 compounds) classified mainly into terpenoids, styrylpyrones, steroids, phenolics, polysaccharides, and other compounds. Numerous novel sesquiterpenoids, triterpenoids, steroids, and styrylpyrones have been isolated from the family. Medicinal properties cover a range of about 100 types of bioactivities, more predominantly antioxidant, antitumor, antidiabetic, immunomodulatory, anti-inflammatory, antibacterial, and antifungal effects. The role of Hymenochaetaceae members in aesthetic medicine is also discussed. Molecular phylogenetic reconstructions reveal that the medicinal species are distributed in 27 monophyletic clades, and 20 medicinal species are types of their respective genera (generic types). So far most of medicinal Hymenochaetaceae species are shown to be distributed in Asia, particularly in China. Considering the drawbacks imposed by improper characterization of Hymenochaetaceae isolates in biomedical studies, general recommendations are given with the aim of encouraging greater focus on accurately identifying the medicinal fungal species.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10612 - Mycology

Projekt

<a href="/cs/project/EF15_003%2F0000453" target="_blank" >EF15_003/0000453: Výzkumné centrum pro studium patogenů z rodu Phytophthora</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mycosphere

ISSN

2077-7000

e-ISSN

2077-7019

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

92

Strana od-do

6347-6438

Kód UT WoS článku

001375812700001

EID výsledku v databázi Scopus

2-s2.0-85214562963