Vliv akutního předávkování železem na chemiluminescenci neutrofilních granulocytů a ukazatele vnitřního prostředí u prasat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F06%3A00000530" target="_blank" >RIV/62157124:16170/06:00000530 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model.

Popis výsledku v původním jazyce

The objective of the study was to evaluate effect of an acute iron dextran on polymorphonuclear cells chemiluminescence and indices of inner environmemt in piglets. The piglets in experimental group (n = 16) were given 2000 mg (20 ml) Fe3+ in the form ofiron dextran i.m. The piglets in control group (n = 13) were given the same amount of physiological solution. The blood was taken before application, 1, 4 and 24 hours thereafter. Iron application resulted in ten times higher concentration of iron in blood plasma in experimental group. No differences in PMA- and OZP- stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of muscle injury at the application site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration.

Název v anglickém jazyce

Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model.

Popis výsledku anglicky

The objective of the study was to evaluate effect of an acute iron dextran on polymorphonuclear cells chemiluminescence and indices of inner environmemt in piglets. The piglets in experimental group (n = 16) were given 2000 mg (20 ml) Fe3+ in the form ofiron dextran i.m. The piglets in control group (n = 13) were given the same amount of physiological solution. The blood was taken before application, 1, 4 and 24 hours thereafter. Iron application resulted in ten times higher concentration of iron in blood plasma in experimental group. No differences in PMA- and OZP- stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of muscle injury at the application site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Svazek periodika

75

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

523-532

Kód UT WoS článku

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EID výsledku v databázi Scopus

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