Differentiation Protocol for Hyaline-cartilage-producing Mesenchymal Stem Cells

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Differentiation Protocol for Hyaline-cartilage-producing Mesenchymal Stem Cells

Popis výsledku v původním jazyce

Recently, the ability of stem cells to differentiate into daughter tissues has become the focus of numerous experiments. After successfully using stem cells in experiments conducted in cardiology and neurology, there has been an increase in experimentalstudies examining the possible ways of exploiting stem cells in orthopaedics and traumatology. Stem cells capable of differentiating into hyaline cartilage can be derived not only from an embryonic stem cell; it is also possible to use mesenchymal stem cells (MSCs), which are found in the bone marrow. Following the isolation of MSCs and the stabilisation of a stem-cell colony, it is necessary to ?direct? the differentiation process towards chondrocytes. The procedure includes properly performed bone-marrow collection and isolation and the identification of a cell line of MSCs by means of CD marker expression. Among the subsequent steps are cell-line cultivation and, particularly, a correct differentiation protocol. In our experimental s

Název v anglickém jazyce

Differentiation Protocol for Hyaline-cartilage-producing Mesenchymal Stem Cells

Popis výsledku anglicky

Recently, the ability of stem cells to differentiate into daughter tissues has become the focus of numerous experiments. After successfully using stem cells in experiments conducted in cardiology and neurology, there has been an increase in experimentalstudies examining the possible ways of exploiting stem cells in orthopaedics and traumatology. Stem cells capable of differentiating into hyaline cartilage can be derived not only from an embryonic stem cell; it is also possible to use mesenchymal stem cells (MSCs), which are found in the bone marrow. Following the isolation of MSCs and the stabilisation of a stem-cell colony, it is necessary to ?direct? the differentiation process towards chondrocytes. The procedure includes properly performed bone-marrow collection and isolation and the identification of a cell line of MSCs by means of CD marker expression. Among the subsequent steps are cell-line cultivation and, particularly, a correct differentiation protocol. In our experimental s

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Musculoskeletal Review

ISSN

1754-5072

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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