Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F11%3A43870601" target="_blank" >RIV/62157124:16170/11:43870601 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11150/11:10104922
Výsledek na webu
<a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >http://dx.doi.org/10.3109/15376516.2011.589089</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/15376516.2011.589089" target="_blank" >10.3109/15376516.2011.589089</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
Popis výsledku v původním jazyce
Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulationof apoptotic processes was evaluated in the present study. Wistar rats (six per group) were exposé subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. Cerebral cortex and livertissues were collected from animals 40 min after exposure. Activities of AChE, glutathione reductase, glutathione-S-transferase, caspase 3, total protein level, thiobarbituric acid reactive substances, reduced glutathione level and ferric reducing antioxidant power (FRAP) were assayed in the tissue samples. Metrifonate had only lower impact on oxidative stress in the liver. Cerebral cortex tissues had decreased AChE and increased caspase 3 activities as well as the FRAP level. Owing to t
Název v anglickém jazyce
Metrifonate alters antioxidant levels and caspase activity in cerebral cortex of Wistar rats
Popis výsledku anglicky
Metrifonate (trichlorfon) is an inhibitor of acetylcholinesterase (AChE). It was used as an Alzheimer's disease (AD) drug; however, the application was withdrawn due to adverse effects. Implication of metrifonate for the antioxidant status and regulationof apoptotic processes was evaluated in the present study. Wistar rats (six per group) were exposé subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. Cerebral cortex and livertissues were collected from animals 40 min after exposure. Activities of AChE, glutathione reductase, glutathione-S-transferase, caspase 3, total protein level, thiobarbituric acid reactive substances, reduced glutathione level and ferric reducing antioxidant power (FRAP) were assayed in the tissue samples. Metrifonate had only lower impact on oxidative stress in the liver. Cerebral cortex tissues had decreased AChE and increased caspase 3 activities as well as the FRAP level. Owing to t
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Toxicology Mechanisms and Methods
ISSN
1537-6516
e-ISSN
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Svazek periodika
21
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
"585?590"
Kód UT WoS článku
000295177300004
EID výsledku v databázi Scopus
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