Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43872753" target="_blank" >RIV/62157124:16170/14:43872753 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16370/14:43872753
Výsledek na webu
<a href="http://dx.doi.org/10.3109/14756366.2013.848204" target="_blank" >http://dx.doi.org/10.3109/14756366.2013.848204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/14756366.2013.848204" target="_blank" >10.3109/14756366.2013.848204</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
Popis výsledku v původním jazyce
Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7b,6b-dihydroxyroyleanone (2), 7b-acetoxy-6b-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and a-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alfa-glucosidase with IC50 values from 33 to 275 mikroM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
Název v anglickém jazyce
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
Popis výsledku anglicky
Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7b,6b-dihydroxyroyleanone (2), 7b-acetoxy-6b-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and a-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alfa-glucosidase with IC50 values from 33 to 275 mikroM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN
1475-6366
e-ISSN
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Svazek periodika
29
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
4
Strana od-do
749-752
Kód UT WoS článku
000342056900020
EID výsledku v databázi Scopus
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