Fas ligand in formation of hard tissues

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873327" target="_blank" >RIV/62157124:16170/14:43873327 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Fas ligand in formation of hard tissues

Popis výsledku v původním jazyce

Among activation of apoptotic machinery, Fas (CD95)/FasL (CD178) were suggested to act in cell proliferation and differentiation. Expression of Fas and FasL was reported during tooth and bone formation. The examination of gld mice showed increased totalbody bone mass and number of osteoblasts in long bones. However, Fas and FasL functions in osteogenesis remain controversial. As most of studies dealing with Fas/FasL system in bone formation were performed in endochondral models, we turned to intramembranous bones. The aim of our study was to investigate functions of FasL in development of the mandibular and alveolar bones using immunohistochemistry and impact of FasL deficiency by microCT examination of gld mice. This project continues our earlier published investigations of Fas/FasL in prenatal molar tooth development. Heads at embryonic (E) 12.5, 15.5, 17.5 and postnatal (P) 0, 1, 4, 11 days were used for immunohistochemical analysis. FasL was localized in the dental epithelium, den

Název v anglickém jazyce

Fas ligand in formation of hard tissues

Popis výsledku anglicky

Among activation of apoptotic machinery, Fas (CD95)/FasL (CD178) were suggested to act in cell proliferation and differentiation. Expression of Fas and FasL was reported during tooth and bone formation. The examination of gld mice showed increased totalbody bone mass and number of osteoblasts in long bones. However, Fas and FasL functions in osteogenesis remain controversial. As most of studies dealing with Fas/FasL system in bone formation were performed in endochondral models, we turned to intramembranous bones. The aim of our study was to investigate functions of FasL in development of the mandibular and alveolar bones using immunohistochemistry and impact of FasL deficiency by microCT examination of gld mice. This project continues our earlier published investigations of Fas/FasL in prenatal molar tooth development. Heads at embryonic (E) 12.5, 15.5, 17.5 and postnatal (P) 0, 1, 4, 11 days were used for immunohistochemical analysis. FasL was localized in the dental epithelium, den

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů