Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873328" target="_blank" >RIV/62157124:16170/14:43873328 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?

Popis výsledku v původním jazyce

Several organs are derived from the ectoderm. Development of these structures is controlled by interplay of proliferation, differentiation and cell death mainly mediated by caspase activation. Caspase-7 together with caspases-3 and -6 belongs to the trioof executive caspases. Despite the primary pro-apoptotic character of these caspases, they have been supposed to play roles in non-apoptotic events. Such non-apoptotic function for caspase-7 was revealed in our laboratory when cleaved caspase-7 was found during differentiation of odontoblasts, ameloblasts, osteoblasts and in other non-apoptotic cells. To find out if such non-apoptotic role of caspase-7 might be linked also to development of other ectoderm-derived organs, mouse hair follicles were investigated. Immunohistochemistry was used to detect cleaved (activated) caspase-7 and correlate its presence with occurrence of apoptosis. To reveal the specific influence of caspase-7 on apoptotic signalling networks, changes of expression

Název v anglickém jazyce

Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?

Popis výsledku anglicky

Several organs are derived from the ectoderm. Development of these structures is controlled by interplay of proliferation, differentiation and cell death mainly mediated by caspase activation. Caspase-7 together with caspases-3 and -6 belongs to the trioof executive caspases. Despite the primary pro-apoptotic character of these caspases, they have been supposed to play roles in non-apoptotic events. Such non-apoptotic function for caspase-7 was revealed in our laboratory when cleaved caspase-7 was found during differentiation of odontoblasts, ameloblasts, osteoblasts and in other non-apoptotic cells. To find out if such non-apoptotic role of caspase-7 might be linked also to development of other ectoderm-derived organs, mouse hair follicles were investigated. Immunohistochemistry was used to detect cleaved (activated) caspase-7 and correlate its presence with occurrence of apoptosis. To reveal the specific influence of caspase-7 on apoptotic signalling networks, changes of expression

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GAP502%2F12%2F1285" target="_blank" >GAP502/12/1285: Apoptotické a neapoptotické funkce kaspáz při formování tvrdých tkání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů